TSPAN31 explained

Tetraspanin-31 is a protein that in humans is encoded by the TSPAN31 gene.^[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma.

Further reading

• Wright MD, Tomlinson MG . The ins and outs of the transmembrane 4 superfamily . Immunol. Today . 15 . 12 . 588–94 . 1995 . 7531445 . 10.1016/0167-5699(94)90222-4 .
• Meltzer PS . Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors . Cell Growth Differ. . 2 . 10 . 495–501 . 1992 . 1661131 . vanc. Jankowski SA . Dal Cin P . 3 . Sandberg . AA . Paz . IB . Coccia . MA .
• Jankowski SA, De Jong P, Meltzer PS . Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas . Genomics . 25 . 2 . 501–6 . 1995 . 7789984 . 10.1016/0888-7543(95)80051-M .
• Jankowski SA . SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins . Oncogene . 9 . 4 . 1205–11 . 1994 . 8134123 . vanc. Mitchell DS . Smith SH . 3 . Trent . JM . Meltzer . PS .
• Elkahloun AG . Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers . Genomics . 42 . 2 . 295–301 . 1997 . 9192850 . 10.1006/geno.1997.4727 . vanc. Krizman DB . Wang Z . 3 . Hofmann . Tiffany A. . Roe . Bruce . Meltzer . Paul S. .
• Wunder JS . Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas . Oncogene . 18 . 3 . 783–8 . 1999 . 9989829 . 10.1038/sj.onc.1202346 . vanc. Eppert K . Burrow SR . 3 . Gogkoz . Nalan . Bell . Robert S . Andrulis . Irene L . free.
• Ragazzini P . Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma . Cancer Detect. Prev. . 23 . 2 . 129–36 . 1999 . 10101594 . 10.1046/j.1525-1500.1999.09907.x . vanc. Gamberi G . Benassi MS . 3 . Orlando . Sestini . Ferrari . Molendini . Sollazzo . Merli . C . R . C . L . MR . M .
• Suzuki Y . Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes . Genome Res. . 11 . 5 . 677–84 . 2001 . 11337467 . 10.1101/gr.gr-1640r. 311086 . vanc. Tsunoda T . Sese J . 3 . Taira . H . Mizushima-Sugano . J . Hata . H . Ota . T . Isogai . T . Tanaka . T .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Ragazzini P . Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma . Histol. Histopathol. . 19 . 2 . 401–11 . 2004 . 15024701 . vanc. Gamberi G . Pazzaglia L . 3 . Serra . M . Magagnoli . G . Ponticelli . F . Ferrari . C . Ghinelli . C . Alberghini . M .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Web site: Entrez Gene: TSPAN31 tetraspanin 31.