TSPAN2 explained

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

Further reading

• Hemler ME . Specific tetraspanin functions . J. Cell Biol. . 155 . 7 . 1103–7 . 2002 . 11756464 . 10.1083/jcb.200108061 . 2199333 .
• Gregory SG . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . Barlow KF . McLay KE . 3 . Kaul . R. . Swarbreck . D. . Dunham . A. . Scott . C. E. . Howe . K. L. . Woodfine . K. . 2006Natur.441..315G . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .

Notes and References

1. Todd SC, Doctor VS, Levy S . Sequences and expression of six new members of the tetraspanin/TM4SF family . Biochim Biophys Acta . 1399 . 1 . 101–4 . Sep 1998 . 9714763 . 10.1016/s0167-4781(98)00087-6. free .
2. Berditchevski F . Complexes of tetraspanins with integrins: more than meets the eye . J Cell Sci . 114 . Pt 23 . 4143–51 . Dec 2001 . 10.1242/jcs.114.23.4143 . 11739647 .
3. Web site: Entrez Gene: TSPAN2 tetraspanin 2.