TSPAN13 explained

Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene.^[1]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.

Further reading

• Böhme E, Graf H, Schultz G . Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets . Advances in Cyclic Nucleotide Research . 9 . 131–43 . 1978 . 27075 .
• Berditchevski F . Complexes of tetraspanins with integrins: more than meets the eye . J. Cell Sci. . 114 . Pt 23 . 4143–51 . 2002 . 10.1242/jcs.114.23.4143 . 11739647 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Serru V, Dessen P, Boucheix C, Rubinstein E . Sequence and expression of seven new tetraspans . Biochim. Biophys. Acta . 1478 . 1 . 159–63 . 2000 . 10719184 . 10.1016/S0167-4838(00)00022-4 .
• Hu RM . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . vanc. Han ZG . Song HD . 3 . Peng . YD . Huang . QH . Ren . SX . Gu . YJ . Huang . CH . Li . YB . 2000PNAS...97.9543H . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Scherer SW . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . vanc. Cheung J . MacDonald JR . 3 . Osborne . LR . Nakabayashi . K . Herbrick . JA . Carson . AR . Parker-Katiraee . L . Skaug . J . 2003Sci...300..767S .
• Clark HF . The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment . Genome Res. . 13 . 10 . 2265–70 . 2003 . 12975309 . 10.1101/gr.1293003 . 403697 . vanc. Gurney AL . Abaya E . 3 . Baker . K . Baldwin . D . Brush . J . Chen . J . Chow . B . Chui . C .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Huang H . Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors . Clin. Cancer Res. . 11 . 12 . 4357–64 . 2005 . 15958618 . 10.1158/1078-0432.CCR-04-2107 . vanc. Groth J . Sossey-Alaoui K . 3 . Hawthorn . L . Beall . S . Geradts . J . free.
• Otsuki T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . vanc. Ota T . Nishikawa T . 3 . Hayashi . K . Suzuki . Y . Yamamoto . J . Wakamatsu . A . Kimura . K . Sakamoto . K . free .
• Moroz MA . Imaging hNET reporter gene expression with 124I-MIBG . J. Nucl. Med. . 48 . 5 . 827–36 . 2007 . 17475971 . 10.2967/jnumed.106.037812 . vanc. Serganova I . Zanzonico P . 3 . Ageyeva . L. . Beresten . T. . Dyomina . E. . Burnazi . E. . Finn . R. D. . Doubrovin . M. . free .

Notes and References

1. Web site: Entrez Gene: TSPAN13 tetraspanin 13.