TSPAN12 explained

Tetraspanin-12 (Tspan-12) also known as tetraspan NET-2 (NET2) or transmembrane 4 superfamily member 12 (TM4SF12) is a tetraspanin protein that in humans is encoded by the TSPAN12 gene. Tetraspanin-12 is found in the membrane of a variety of cells. It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.

Function

Its main binding partner is the ADAM10 protein,[1] a sheddase that interacts with a variety of adhesion molecules that are found on the cell membrane including L1-CAM, E-Cadherin, N-Cadherin and CD44.[2] [3] It also binds to the MT1-MMP metalloprotease protein that is closely related to ADAM10 but has a minimal effect on promotion of expression and function.[4] TSPAN12 also seems to regulate vascular development, as shown by a study involving TSPAN12 knockout mice.[5] TSPAN12 is a significant contributor to primary and metastatic cancer and is responsible for protecting β-catenin from degradation.[6]

External links

Notes and References

  1. Xu D, Sharma C, Hemler ME . Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein . FASEB J. . 23 . 11 . 3674–81 . November 2009 . 19587294 . 2775005 . 10.1096/fj.09-133462 . free .
  2. Lee SB, Schramme A, Doberstein K, Dummer R, Abdel-Bakky MS, Keller S, Altevogt P, Oh ST, Reichrath J, Oxmann D, Pfeilschifter J, Mihic-Probst D, Gutwein P . ADAM10 is upregulated in melanoma metastasis compared with primary melanoma . J. Invest. Dermatol. . 130 . 3 . 763–73 . March 2010 . 19865098 . 10.1038/jid.2009.335 . free .
  3. Anderegg U, Eichenberg T, Parthaune T, Haiduk C, Saalbach A, Milkova L, Ludwig A, Grosche J, Averbeck M, Gebhardt C, Voelcker V, Sleeman JP, Simon JC . ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells . J. Invest. Dermatol. . 129 . 6 . 1471–82 . June 2009 . 18971959 . 10.1038/jid.2008.323 . free .
  4. Lafleur MA, Xu D, Hemler ME . Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis . Mol. Biol. Cell . 20 . 7 . 2030–40 . April 2009 . 19211836 . 2663921 . 10.1091/mbc.E08-11-1149 .
  5. Junge HJ, Yang S, Burton JB, Paes K, Shu X, French DM, Costa M, Rice DS, Ye W . TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling . Cell . 139 . 2 . 299–311 . October 2009 . 19837033 . 10.1016/j.cell.2009.07.048 . 2276711 . free .
  6. Knoblich K, Wang HX, Sharma C, Fletcher AL, Turley SJ, Hemler ME . Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation . Cell Mol Life Sci . 71 . 7 . 1305–14 . April 2014 . 23955570 . 10.1007/s00018-013-1444-8 . 16135992 . 11113286 .

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