Translin-associated factor X explained

Translin-associated protein X (abbr. TSNAX or TRAX) is a protein that in humans is encoded by the TSNAX gene.^{[1] [2]}

Function

This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. Both TSNAX and translin form the C3PO complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).^[3]

Interactions

TSNAX has been shown to interact with C1D.^[4]

Further reading

• Millar JK, Christie S, Semple CA, Porteous DJ . Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia . Genomics . 67 . 1 . 69–77 . Jul 2000 . 10945471 . 10.1006/geno.2000.6239 .
• Meng G, Aoki K, Tokura K, Nakahara K, Inazawa J, Kasai M . Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X . Journal of Human Genetics . 45 . 5 . 305–8 . 2000 . 11043515 . 10.1007/s100380070022 . free .
• Chennathukuzhi VM, Kurihara Y, Bray JD, Hecht NB . Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA . The Journal of Biological Chemistry . 276 . 16 . 13256–63 . Apr 2001 . 11278549 . 10.1074/jbc.M009707200 . free .
• Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U . DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX) . Journal of Cell Science . 115 . Pt 1 . 207–16 . Jan 2002 . 10.1242/jcs.115.1.207 . 11801738 . 11693/24740 . free .
• Bray JD, Chennathukuzhi VM, Hecht NB . Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X . Genomics . 79 . 6 . 799–808 . Jun 2002 . 12036294 . 10.1006/geno.2002.6779 .
• Wu RF, Osatomi K, Terada LS, Uyeda K . Identification of Translin/Trax complex as a glucose response element binding protein in liver . Biochimica et Biophysica Acta (BBA) - General Subjects . 1624 . 1–3 . 29–35 . Dec 2003 . 14642810 . 10.1016/j.bbagen.2003.09.002 .
• Yang S, Cho YS, Chennathukuzhi VM, Underkoffler LA, Loomes K, Hecht NB . Translin-associated factor X is post-transcriptionally regulated by its partner protein TB-RBP, and both are essential for normal cell proliferation . The Journal of Biological Chemistry . 279 . 13 . 12605–14 . Mar 2004 . 14711818 . 10.1074/jbc.M313133200 . free .
• Gocke CB, Yu H, Kang J . Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates . The Journal of Biological Chemistry . 280 . 6 . 5004–12 . Feb 2005 . 15561718 . 10.1074/jbc.M411718200 . free .
• Thomson PA, Wray NR, Millar JK, Evans KL, Hellard SL, Condie A, Muir WJ, Blackwood DH, Porteous DJ . Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population . Molecular Psychiatry . 10 . 7 . 657–68, 616 . Jul 2005 . 15838535 . 10.1038/sj.mp.4001669 . 144686652 .
• Gupta GD, Makde RD, Kamdar RP, D'Souza JS, Kulkarni MG, Kumar V, Rao BJ . Co-expressed recombinant human Translin-Trax complex binds DNA . FEBS Letters . 579 . 14 . 3141–6 . Jun 2005 . 15919079 . 10.1016/j.febslet.2005.05.007 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Aoki K, Ishida R, Kasai M . Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX . FEBS Letters . 401 . 2–3 . 109–12 . Jan 1997 . 9013868 . 10.1016/S0014-5793(96)01444-5 . 46704829 .
2. Web site: Entrez Gene: TSNAX translin-associated factor X.
3. Ha M, Kim VN . Regulation of microRNA biogenesis . Nature Reviews Molecular Cell Biology . 15 . 8 . 509–24 . Aug 2014 . 25027649 . 10.1038/nrm3838 . 205495632 .
4. Erdemir T, Bilican B, Oncel D, Goding CR, Yavuzer U . DNA damage-dependent interaction of the nuclear matrix protein C1D with Translin-associated factor X (TRAX) . Journal of Cell Science . 115 . Pt 1 . 207–16 . Jan 2002 . 10.1242/jcs.115.1.207 . 11801738 . 11693/24740 . free .