TSHB explained

Thyroid stimulating hormone, beta also known as TSHB is a protein which in humans is encoded by the TSHB gene.^{[1] [2]}

Function

Thyrotropin-stimulating hormone (TSH) is a noncovalently linked glycoprotein heterodimer and is part of a family of pituitary hormones containing a common alpha subunit (TSHA) and a unique beta subunit (this protein) that confers specificity.^[3]

See also

• thyroid stimulating hormone

Further reading

• Bonomi M, Proverbio MC, Weber G, etal . Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene. . J. Clin. Endocrinol. Metab. . 86 . 4 . 1600–4 . 2001 . 10.1210/jcem.86.4.7411 . 11297590 . free .
• Vuissoz JM, Deladoëy J, Buyukgebiz A . New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism. . J. Clin. Endocrinol. Metab. . 86 . 9 . 4468–71 . 2001 . 10.1210/jcem.86.9.7876 . 11549695 . etal. free .
• Karges B, LeHeup B, Schoenle E, etal . Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe. . Horm. Res. . 62 . 3 . 149–55 . 2004 . 15297803 . 10.1159/000080071 . 28309388 .
• Kabadi UM, Premachandra BN . Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function? . Endocr Pract . 13 . 6 . 615–9 . 2007 . 17954417 . 10.4158/ep.13.6.615.
• Miyai S, Yoshimura S, Iwasaki Y, etal . Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line. . Cell Tissue Res. . 322 . 2 . 269–77 . 2005 . 16133148 . 10.1007/s00441-005-0033-z . 37186810 .
• Pierce JG . Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones. . Endocrinology . 89 . 6 . 1331–44 . 1971 . 5002675 . 10.1210/endo-89-6-1331 .
• Atzmon G, Barzilai N, Surks MI, Gabriely I . Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity . J. Clin. Endocrinol. Metab. . 94 . 12 . 4768–75 . 2009 . 19837933 . 10.1210/jc.2009-0808 . 2795660 .
• Landa I, Ruiz-Llorente S, Montero-Conde C, etal . The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors . PLOS Genet. . 5 . 9 . e1000637 . 2009 . 19730683 . 10.1371/journal.pgen.1000637 . 2727793 . Gibson . Greg . free .
• Pohlenz J, Dumitrescu A, Aumann U, etal . Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene . J. Clin. Endocrinol. Metab. . 87 . 1 . 336–9 . 2002 . 10.1210/jcem.87.1.8154 . 11788671 . free .
• Miyoshi I, Kasai N, Hayashizaki Y . [Structure and regulation of human thyroid-stimulating hormone (TSH) gene] . Nippon Rinsho . 52 . 4 . 940–7 . 1994 . 8196184 .
• Borck G, Topaloglu AK, Korsch E, etal . Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect . J. Clin. Endocrinol. Metab. . 89 . 8 . 4136–41 . 2004 . 15292359 . 10.1210/jc.2004-0494 . free .
• Comings DE, Gade-Andavolu R, Gonzalez N, etal . A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory . Clin. Genet. . 58 . 5 . 375–85 . 2000 . 11140838 . 10.1034/j.1399-0004.2000.580508.x . 14733771 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Clark AG, Glanowski S, Nielsen R, etal . Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios . Science . 302 . 5652 . 1960–3 . 2003 . 14671302 . 10.1126/science.1088821 . 2003Sci...302.1960C . 6682593 .
• Loinder K, Söderström M . An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene . J. Steroid Biochem. Mol. Biol. . 97 . 4 . 322–7 . 2005 . 16216492 . 10.1016/j.jsbmb.2005.06.031 . 45326566 .
• Luttrell LM . Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors . Mol. Biotechnol. . 39 . 3 . 239–64 . 2008 . 18240029 . 10.1007/s12033-008-9031-1 . 45173229 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Brumm H, Pfeufer A, Biebermann H, etal . Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect . J. Clin. Endocrinol. Metab. . 87 . 10 . 4811–6 . 2002 . 12364478 . 10.1210/jc.2002-020297 . free .
• Benhadi N, Wiersinga WM, Reitsma JB, etal . Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death . Eur. J. Endocrinol. . 160 . 6 . 985–91 . 2009 . 19273570 . 10.1530/EJE-08-0953 . free .
• Schaefer JS, Klein JR . A novel thyroid stimulating hormone β-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid . Gen. Comp. Endocrinol. . 162 . 3 . 241–4 . 2009 . 19364510 . 10.1016/j.ygcen.2009.04.006 . 2689139 .

Notes and References

1. Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD . Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species . J. Biol. Chem. . 263 . 25 . 12538–42 . September 1988 . 10.1016/S0021-9258(18)37788-3 . 2457586 . free .
2. Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K . The structure of the human thyrotropin beta-subunit gene . Gene . 73 . 2 . 489–97 . December 1988 . 3243440 . 10.1016/0378-1119(88)90513-6.
3. Web site: Entrez Gene: TSHB .