TSEN15 explained

tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene.^{[1] [2] [3]}

tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM]^[3]

Interactions

C1orf19 has been shown to interact with TSEN2.^[4]

Further reading

• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . 6 . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . July 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–23 . July 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR . Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation . Cell . 117 . 3 . 311–21 . April 2004 . 15109492 . 10.1016/S0092-8674(04)00342-3 . 16049289 . free .

Notes and References

1. Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD . 6 . Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus . Genomics . 73 . 2 . 211–22 . April 2001 . 11318611 . 10.1006/geno.2001.6500 .
2. Song J, Markley JL . Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold . Journal of Molecular Biology . 366 . 1 . 155–64 . February 2007 . 17166513 . 1865571 . 10.1016/j.jmb.2006.11.024 .
3. Web site: Entrez Gene: C1orf19 chromosome 1 open reading frame 19.
4. Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR . Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation . Cell . 117 . 3 . 311–21 . April 2004 . 15109492 . 10.1016/S0092-8674(04)00342-3 . 16049289 . free .