TSC22D1 explained

TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.^{[1] [2]}

TSC22 encodes a transcription factor and belongs to the large family of early response genes.^[3]

TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.^[4]

Further reading

• Shibanuma M, Kuroki T, Nose K . Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors. . J. Biol. Chem. . 267 . 15 . 10219–24 . 1992 . 10.1016/S0021-9258(19)50006-0 . 1587811 . free .
• Dmitrenko VV, Garifulin OM, Shostak EA, etal . [The characteristics of different types of mRNA expressed in the human brain] . Tsitol. Genet. . 30 . 5 . 41–7 . 1997 . 9026990 .
• Kester HA, Blanchetot C, den Hertog J, etal . Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity. . J. Biol. Chem. . 274 . 39 . 27439–47 . 1999 . 10488076 . 10.1074/jbc.274.39.27439 . free .
• Hino S, Kawamata H, Uchida D, etal . Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator. . Biochem. Biophys. Res. Commun. . 278 . 3 . 659–64 . 2001 . 11095965 . 10.1006/bbrc.2000.3840 .
• Hino S, Kawamata H, Omotehara F, etal . Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells. . Oncol. Rep. . 9 . 2 . 371–4 . 2002 . 11836610 . 10.3892/or.9.2.371.
• Hino S, Kawamata H, Omotehara F, etal . Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells. . Biochem. Biophys. Res. Commun. . 292 . 4 . 957–63 . 2002 . 11944908 . 10.1006/bbrc.2002.6776 .
• Ohara O, Nagase T, Mitsui G, etal . Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. . DNA Res. . 9 . 2 . 47–57 . 2003 . 12056414 . 10.1093/dnares/9.2.47 . free .
• Gupta RA, Sarraf P, Brockman JA, etal . Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22. . J. Biol. Chem. . 278 . 9 . 7431–8 . 2003 . 12468551 . 10.1074/jbc.M208076200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Sugawara F, Yamada Y, Watanabe R, etal . The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy. . Diabetes Res. Clin. Pract. . 60 . 3 . 191–7 . 2004 . 12757981 . 10.1016/S0168-8227(03)00038-X .
• Uchida D, Omotehara F, Nakashiro K, etal . Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1. . Biochem. Biophys. Res. Commun. . 305 . 4 . 846–54 . 2003 . 12767908 . 10.1016/S0006-291X(03)00854-4 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Choi SJ, Moon JH, Ahn YW, etal . Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation. . Mol. Cell. Biochem. . 271 . 1–2 . 23–8 . 2005 . 15881652 . 10.1007/s11010-005-3456-7 . 23414101 .
• Rentsch CA, Cecchini MG, Schwaninger R, etal . Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer. . Int. J. Cancer . 118 . 4 . 899–906 . 2006 . 16106424 . 10.1002/ijc.21449 . 44422160 . free .
• Stelzl U, Worm U, Lalowski M, etal . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . free . 11858/00-001M-0000-0010-8592-0 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Lu Y, Kitaura J, Oki T, etal . Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD. . Leukemia . 21 . 11 . 2246–57 . 2007 . 17690703 . 10.1038/sj.leu.2404883 . 2787939 .

Notes and References

1. Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P . Cloning of the human homologue of the TGF beta-stimulated clone 22 gene . Biochem Biophys Res Commun . 222 . 3 . 821–6 . Jul 1996 . 8651929 . 10.1006/bbrc.1996.0825 .
2. Ohta S, Shimekake Y, Nagata K . Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter . Eur J Biochem . 242 . 3 . 460–6 . Mar 1997 . 9022669 . 10.1111/j.1432-1033.1996.460rr.x . free .
3. Web site: Entrez Gene: TSC22D1 TSC22 domain family, member 1.
4. Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B . Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity . J. Biol. Chem. . 274 . 39 . 27439–47 . September 1999 . 10488076 . 10.1074/jbc.274.39.27439 . free .