MCOLN2 explained

Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene.^[1] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins.^[2]

See also

• transient receptor potential cation channel, mucolipin subfamily, member 1 (MCOLN1)
• transient receptor potential cation channel, mucolipin subfamily, member 3 (MCOLN3)
• TRPML

Notes and References

1. Clapham DE, Julius D, Montell C, Schultz G . International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels . Pharmacol. Rev. . 57 . 4 . 427–50 . December 2005 . 16382100 . 10.1124/pr.57.4.6 . 17936350 .
2. Karacsonyi C, Miguel AS, Puertollano R . Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs . Traffic . 8 . 10 . 1404–14 . October 2007 . 17662026 . 10.1111/j.1600-0854.2007.00619.x . 25624298 . free .