TRPM4 explained

Transient receptor potential cation channel subfamily M member 4 (hTRPM4), also known as melastatin-4, is a protein that in humans is encoded by the TRPM4 gene.^{[1] [2]}

TRPM4 Channel Blocker

• 9-Phenanthrol
• TRPM4-IN-5

See also

• TRPM

Further reading

• Book: Islam, Md. Shahidul . Transient Receptor Potential Channels . January 2011 . 704 . Springer . Berlin . 700 . Advances in Experimental Medicine and Biology . 978-94-007-0264-6 .
• Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP . TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization . Cell . 109. 3 . 397–407 . 2002 . 12015988 . 10.1016/S0092-8674(02)00719-5 . 14411824 . free .
• Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP . TRPM4 regulates calcium oscillations after T cell activation . Science . 306 . 5700 . 1374–1377 . 2004 . 15550671 . 10.1126/science.1098845 . 2004Sci...306.1374L . 16459097 .
• Book: Vennekens R, Nilius B . Transient Receptor Potential (TRP) Channels . Insights into TRPM4 function, regulation and physiological role . 179. . 269–85 . 2007 . 17217063 . 10.1007/978-3-540-34891-7_16 . Handbook of Experimental Pharmacology . 978-3-540-34889-4 .
• Vennekens R, Olausson J, Meissner M, Bloch W, Mathar I, Philipp SE, Schmitz F, Weissgerber P, Nilius B, Flockerzi V, Freichel M . Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4 . Nat Immunol . 8 . 3 . 312–320 . 2007 . 17293867 . 10.1038/ni1441 . 29303898 .
• Barbet G, Demion M, Moura IC, Serafini N, Léger T, Vrtovsnik F, Monteiro RC, Guinamard R, Kinet JP, Launay P . The calcium-activated nonselective cation channel TRPM4 is essential for the migration but not the maturation of dendritic cells . Nat Immunol . 9 . 10 . 1148–56 . 2008 . 18758465 . 10.1038/ni.1648 . 2956271 .

Notes and References

1. Xu XZ, Moebius F, Gill DL, Montell C . Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform . Proc. Natl. Acad. Sci. U.S.A. . 98 . 19 . 10692–7 . September 2001 . 11535825 . 58528 . 10.1073/pnas.191360198 . free . 2001PNAS...9810692X .
2. Clapham DE, Julius D, Montell C, Schultz G . International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels . Pharmacol. Rev. . 57 . 4 . 427–50 . December 2005 . 16382100 . 10.1124/pr.57.4.6 . 17936350 .