TRNA sulfurtransferase explained
| tRNA sulfurtransferase |
| Ec Number: | 2.8.1.4 |
| Cas Number: | 9055-57-6 |
| Go Code: | 0016227 |
In enzymology, a tRNA sulfurtransferase is an enzyme that catalyzes the chemical reaction
L-cysteine + 'activated' tRNA
L-serine + tRNA containing a thionucleotide
Thus, the two substrates of this enzyme are L-cysteine and 'activated' tRNA, whereas its two products are L-serine and tRNA containing a thionucleotide.
This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is L-cysteine:tRNA sulfurtransferase. Other names in common use include transfer ribonucleate sulfurtransferase, RNA sulfurtransferase, ribonucleate sulfurtransferase, transfer RNA sulfurtransferase, and transfer RNA thiolase.
References
- Abrell JW, Kaufman EE, Lipsett MN . 1971 . The biosynthesis of 4-thiouridylate. Separation and purification of two enzymes in the transfer ribonucleic acid-sulfurtransferase system . J. Biol. Chem. . 246 . 294 - 301 . 5541999 . 2 . 10.1016/S0021-9258(18)62490-1 . free .
- Hayward RS, Weiss SB . 1966 . RNA thiolase: the enzymatic transfer of sulfur from cysteine to sRNA in Escherichia coli extracts . Proc. Natl. Acad. Sci. U.S.A. . 55 . 1161 - 8 . 5334200 . 10.1073/pnas.55.5.1161 . 5 . 224294 . free .
- Lipsett MN, Peterkofsky A . 1966 . Enzymatic thiolation of E. coli sRNA . Proc. Natl. Acad. Sci. U.S.A. . 55 . 1169 - 74 . 5334201 . 10.1073/pnas.55.5.1169 . 5 . 224295 . free .
- Wong TW, Weiss SB, Eliceiri GL, Bryant J . 1970 . Ribonucleic acid sulfurtransferase from Bacillus subtilis W168 Sulfuration with beta-mercaptopyruvate and properties of the enzyme system . Biochemistry . 9 . 2376 - 86 . 4987417 . 10.1021/bi00813a024 . 11 .
