TRNA (guanine6-N2)-methyltransferase explained

TRNA (guanine^6-N^2)-methyltransferase
Ec Number:	2.1.1.256

TRNA (guanine⁶-N²)-methyltransferase (methyltransferase Trm14, m2G6 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine⁶-N²)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine⁶ in tRNA

\rightleftharpoons S-adenosyl-L-homocysteine + N²-methylguanine⁶ in tRNA

The enzyme specifically methylates guanine⁶ at N² in tRNA.

Notes and References

1. Menezes S, Gaston KW, Krivos KL, Apolinario EE, Reich NO, Sowers KR, Limbach PA, Perona JJ . Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14 . Nucleic Acids Research . 39 . 17 . 7641–55 . September 2011 . 21693558 . 3177210 . 10.1093/nar/gkr475 .