TRNA (cytosine38-C5)-methyltransferase explained

TRNA (cytosine38-C5)-methyltransferase
Ec Number:	2.1.1.204

TRNA (cytosine38-C5)-methyltransferase (hDNMT2 (gene), DNMT2 (gene), TRDMT1 (gene)) is an enzyme with the systematic name S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction:

S-adenosyl-L-methionine + cytosine³⁸ in tRNA

\rightleftharpoons S-adenosyl-L-homocysteine + 5-methylcytosine³⁸ in tRNA

The eukaryotic enzyme catalyses methylation of cytosine³⁸ in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC).

See also

• TRDMT1

Notes and References

1. Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH . Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2 . Science . 311 . 5759 . 395–8 . January 2006 . 16424344 . 10.1126/science.1120976 .
2. Jurkowski TP, Meusburger M, Phalke S, Helm M, Nellen W, Reuter G, Jeltsch A . Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism . RNA . 14 . 8 . 1663–70 . August 2008 . 18567810 . 2491481 . 10.1261/rna.970408 .
3. Schaefer M, Pollex T, Hanna K, Tuorto F, Meusburger M, Helm M, Lyko F . RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage . Genes & Development . 24 . 15 . 1590–5 . August 2010 . 20679393 . 2912555 . 10.1101/gad.586710 .