TRNA (cytidine56-2'-O)-methyltransferase explained

tRNA (cytidine56-2'-O)-methyltransferase
Ec Number:	2.1.1.206

tRNA (cytidine56-2'-O)-methyltransferase (aTrm⁵⁶, tRNA ribose 2'-O-methyltransferase aTrm⁵⁶, PAB1040 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons S-adenosyl-L-homocysteine + 2'-O-methylcytidine⁵⁶ in tRNA

The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.

Notes and References

1. Renalier MH, Joseph N, Gaspin C, Thebault P, Mougin A . The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP . RNA . 11 . 7 . 1051–63 . July 2005 . 15987815 . 1370790 . 10.1261/rna.2110805 .
2. Kuratani M, Bessho Y, Nishimoto M, Grosjean H, Yokoyama S . Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA . Journal of Molecular Biology . 375 . 4 . 1064–75 . January 2008 . 18068186 . 10.1016/j.jmb.2007.11.023 .