TRNA (cytidine32/guanosine34-2'-O)-methyltransferase explained

TRNA (cytidine32/guanosine34-2'-O)-methyltransferase
Ec Number:2.1.1.205

TRNA (cytidine32/guanosine34-2'-O)-methyltransferase (Trm7p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

\rightleftharpoons

S-adenosyl-L-homocysteine + 2'-O-methylcytidine32/2'-O-methylguanosine34 in tRNA

The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe and tRNATrp.

Notes and References

  1. Pintard L, Lecointe F, Bujnicki JM, Bonnerot C, Grosjean H, Lapeyre B . Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop . The EMBO Journal . 21 . 7 . 1811–20 . April 2002 . 11927565 . 125368 . 10.1093/emboj/21.7.1811 .

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