TRNA (adenine-N6-)-methyltransferase explained

tRNA (adenine-N6-)-methyltransferase
Ec Number:	2.1.1.55
Cas Number:	9014-53-3
Go Code:	0016430

In enzymology, a tRNA (adenine-N6-)-methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA

\rightleftharpoons S-adenosyl-L-homocysteine + tRNA containing N₆-methyladenine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N6-methyladenine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase. This enzyme is also called S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase.

References

• Mandel LR, Hacker B, Maag TA . 1971 . Altered transfer RNA methylase patterns in Marek's disease tumors . Cancer Res. . 31 . 613 - 6 . 4996578 . 5 .
• Mittelman A, Hall RH, Yohn DS, ((Grace JT Jr)) . 1967 . The in vitro soluble RNA methylase activity of SV40-induced hamster tumors . Cancer Res. . 27 . 1409 - 14 . 4292682 . 8 .
• Sharma OK . 1973 . Differences in the transfer RNA methyltransferases from normal rat liver and Novikoff hepatoma . Biochim. Biophys. Acta . 299 . 415 - 27 . 4349332 . 3 . 10.1016/0005-2787(73)90266-9.