TRNA (adenine-N1-)-methyltransferase explained

tRNA (adenine-N1-)-methyltransferase
Ec Number:	2.1.1.36
Cas Number:	37257-03-7
Go Code:	0016429

In enzymology, a tRNA (adenine-N1-)-methyltransferase is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA

\rightleftharpoons S-adenosyl-L-homocysteine + tRNA containing N₁-methyladenine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N1-methyladenine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase. Other names in common use include transfer ribonucleate adenine 1-methyltransferase, transfer RNA (adenine-1) methyltransferase, 1-methyladenine transfer RNA methyltransferase, adenine-1-methylase, and S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase.

References

• Baguley BC, Staehelin M . 1968 . The specificity of transfer ribonucleic acid methylases from rat liver . Biochemistry . 7 . 45 - 50 . 4921283 . 10.1021/bi00841a007 . 1 .
• Bjork GR, Svensson I . 1969 . Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae . Eur. J. Biochem. . 9 . 207 - 15 . 4896260 . 10.1111/j.1432-1033.1969.tb00596.x . 2 . free .
• Dubois EG, Dirheimer G, Weil JH . 1974 . Methylation of yeast tRNA Asp by enzymes from cytoplasm, chloroplasts and mitochondria of phaseolus vulgaris . Biochim. Biophys. Acta . 374 . 332 - 41 . 4611497 . 3 . 10.1016/0005-2787(74)90254-8.
• Glick JM, Leboy PS . 1977 . Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver . J. Biol. Chem. . 252 . 4790 - 5 . 17605 . 14 .