TRNAMet cytidine acetyltransferase explained

TRNAMet cytidine acetyltransferase
Ec Number:	2.3.1.193

TRNAMet cytidine acetyltransferase (YpfI, TmcA) is an enzyme with systematic name acetyl-CoA:(elongator tRNAMet)-cytidine³⁴ N⁴-acetyltransferase (ATP-hydrolysing).^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons CoA + [elongator tRNAMet]-N⁴-acetylcytidine³⁴ + ADP + phosphate

The enzyme acetylates the wobble base C³⁴ of the CAU anticodon of elongation-specific tRNAMet.

Notes and References

1. Ikeuchi Y, Kitahara K, Suzuki T . The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon . The EMBO Journal . 27 . 16 . 2194–203 . August 2008 . 18668122 . 2500205 . 10.1038/emboj.2008.154 .
2. Chimnaronk S, Suzuki T, Manita T, Ikeuchi Y, Yao M, Suzuki T, Tanaka I . RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon . The EMBO Journal . 28 . 9 . 1362–73 . May 2009 . 19322199 . 2683049 . 10.1038/emboj.2009.69 .