TRNA1Val (adenine37-N6)-methyltransferase explained

TRNA1Val (adenine^37-N^6)-methyltransferase
Ec Number:	2.1.1.223

TRNA1Val (adenine³⁷-N⁶)-methyltransferase (YfiC) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA1Val (adenine³⁷-N⁶)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine³⁷ in tRNA1Val

\rightleftharpoons S-adenosyl-L-homocysteine + N⁶-methyladenine³⁷ in tRNA1Val

The enzyme specifically methylates adenine³⁷ in tRNA1Val (anticodon cmo5UAC).

Notes and References

1. Golovina AY, Sergiev PV, Golovin AV, Serebryakova MV, Demina I, Govorun VM, Dontsova OA . The yfiC gene of E. coli encodes an adenine-N6 methyltransferase that specifically modifies A37 of tRNA1Val(cmo5UAC) . RNA . 15 . 6 . 1134–41 . June 2009 . 19383770 . 2685529 . 10.1261/rna.1494409 .