TRNA-dihydrouridine47 synthase (NAD(P)+) explained

TRNA-dihydrouridine47 synthase (NAD(P)+)
Ec Number:1.3.1.89

TRNA-dihydrouridine47 synthase (NAD(P)+) (Dus3p, tRNA-dihydrouridine synthase 3) is an enzyme with systematic name tRNA-5,6-dihydrouracil47:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

5,6-dihydrouracil47 in tRNA + NAD(P)+

\rightleftharpoons

uracil47 in tRNA + NAD(P)H + H+

This enzyme specifically modifies uracil47 in tRNA.

Notes and References

  1. Xing F, Hiley SL, Hughes TR, Phizicky EM . The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs . The Journal of Biological Chemistry . 279 . 17 . 17850–60 . April 2004 . 14970222 . 10.1074/jbc.M401221200 . free .

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