TRMU explained

Mitochondrial tRNA-specific 2-thiouridylase 1 is an enzyme that in humans is encoded by the TRMU gene.^{[1] [2]}

This gene is a member of the trmU family. It encodes a mitochondria-specific tRNA-modifying enzyme that is required for the 2-thio modification of 5-taurinomethyl-2-thiouridine tRNA-Lys on the wobble position of the anticodon.

Further reading

• Dunham I . The DNA sequence of human chromosome 22 . Nature . 402 . 6761 . 489–95 . 1999 . 10591208 . 10.1038/990031 . vanc. Shimizu N . Roe BA . 3 . Bruskiewich . R. . Beare . D. M. . Clamp . M. . Smink . L. J. . Ainscough . R. . Almeida . J. P. . 1999Natur.402..489D . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Collins JE . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . vanc. Wright CL . Edwards CA . 3 . Davis . Matthew P . Grinham . James A . Cole . Charlotte G . Goward . Melanie E . Aguado . Begoña . Mallya . Meera . free .
• Umeda N . Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases . J. Biol. Chem. . 280 . 2 . 1613–24 . 2005 . 15509579 . 10.1074/jbc.M409306200 . vanc. Suzuki T . Yukawa M . 3 . Ohya . Y . Shindo . H . Watanabe . K . Suzuki . T . free .
• Yan Q, Li X, Faye G, Guan MX . Mutations in MTO2 Related to tRNA Modification Impair Mitochondrial Gene Expression and Protein Synthesis in the Presence of a Paromomycin Resistance Mutation in Mitochondrial 15 S rRNA . J. Biol. Chem. . 280 . 32 . 29151–7 . 2005 . 15944150 . 2905382 . 10.1074/jbc.M504247200 . free .
• Oh JH . Transcriptome analysis of human gastric cancer . Mamm. Genome . 16 . 12 . 942–54 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . vanc. Yang JO . Hahn Y . 3 . Kim . Mi-Rang . Byun . Sang-Soon . Jeon . Yeo-Jin . Kim . Jeong-Min . Song . Kyu-Sang . Noh . Seung-Moo . 69278 .
• Yan Q . Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations . Biochem. Biophys. Res. Commun. . 342 . 4 . 1130–6 . 2006 . 16513084 . 10.1016/j.bbrc.2006.02.078 . vanc. Bykhovskaya Y . Li R . 3 . Mengesha . Emebet . Shohat . Mordechai . Estivill . Xavier . Fischel-Ghodsian . Nathan . Guan . Min-Xin .
• Guan MX . Mutation in TRMU Related to Transfer RNA Modification Modulates the Phenotypic Expression of the Deafness-Associated Mitochondrial 12S Ribosomal RNA Mutations . Am. J. Hum. Genet. . 79 . 2 . 291–302 . 2006 . 16826519 . 10.1086/506389 . 1559489 . vanc. Yan Q . Li X . 3 . Bykhovskaya . Yelena . Gallo-Teran . Jaime . Hajek . Petr . Umeda . Noriko . Zhao . Hui . Garrido . Gema .

Notes and References

1. Yan Q, Guan MX . Identification and characterization of mouse TRMU gene encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase . Biochim Biophys Acta . 1676 . 2 . 119–26 . Jan 2004 . 14746906 . 10.1016/j.bbaexp.2003.11.010.
2. Web site: Entrez Gene: TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase.