TRMT12 explained

tRNA wybutosine-synthesizing protein 2 homolog is a protein that in humans is encoded by the TRMT12 gene.^{[1] [2] [3]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rodriguez V, Chen Y, Elkahloun A, etal . Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer . Genes Chromosomes Cancer . 46 . 7 . 694–707 . 2007 . 17440925 . 10.1002/gcc.20454 . 36237771 .

Notes and References

1. Kalhor HR, Penjwini M, Clarke S . A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA . Biochem Biophys Res Commun . 334 . 2 . 433–40 . Jul 2005 . 16005430 . 10.1016/j.bbrc.2005.06.111 .
2. Noma A, Suzuki T . Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis . Nucleic Acids Symp Ser (Oxf) . 50. 50 . 65–6 . Dec 2006 . 17150819 . 10.1093/nass/nrl032 .
3. Web site: Entrez Gene: TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae).