TRIT1 explained

tRNA isopentenyltransferase, mitochondrial is an enzyme that in humans is encoded by the TRIT1 gene.

It catalyzes the addition of an isopentenyl group from dimethylallyl diphosphate (DMAPP) onto adenosine residue 37 of certain tRNA molecules.^{[1] [2] [3]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Lemieux J, Lakowski B, Webb A, etal . Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria . Genetics . 159 . 1 . 147–57 . 2002 . 10.1093/genetics/159.1.147 . 11560893 . 1461807 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Spinola M, Falvella FS, Galvan A, etal . Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival . Lung Cancer . 55 . 3 . 271–7 . 2007 . 17145094 . 10.1016/j.lungcan.2006.10.023 . 2434/25016 . free .

Notes and References

1. Golovko A, Hjalm G, Sitbon F, Nicander B . Cloning of a human tRNA isopentenyl transferase . Gene . 258 . 1–2 . 85–93 . Jan 2001 . 11111046 . 10.1016/S0378-1119(00)00421-2 .
2. Spinola M, Galvan A, Pignatiello C, Conti B, Pastorino U, Nicander B, Paroni R, Dragani TA . Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer . Oncogene . 24 . 35 . 5502–9 . Aug 2005 . 15870694 . 10.1038/sj.onc.1208687 . free .
3. Web site: Entrez Gene: TRIT1 tRNA isopentenyltransferase 1.