TRIP6 explained

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.^{[1] [2] [3]}

Function

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Interactions

TRIP6 has been shown to interact with LPAR2,^[4] BCAR1^{[4] [5]} and HOXA9.^[6]

Further reading

• Williams JM, Chen GC, Zhu L, Rest RF . Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth . Molecular Microbiology . 27 . 1 . 171–86 . Jan 1998 . 9466265 . 10.1046/j.1365-2958.1998.00670.x . 36570024 . free .
• Murthy KK, Clark K, Fortin Y, Shen SH, Banville D . ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E . The Journal of Biological Chemistry . 274 . 29 . 20679–87 . Jul 1999 . 10400701 . 10.1074/jbc.274.29.20679 . free .
• Zhao MK, Wang Y, Murphy K, Yi J, Beckerle MC, Gilmore TD . LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor . Gene Expression . 8 . 4 . 207–17 . 2000 . 10794523 . 6157364 .
• Cuppen E, van Ham M, Wansink DG, de Leeuw A, Wieringa B, Hendriks W . The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL . European Journal of Cell Biology . 79 . 4 . 283–93 . Apr 2000 . 10826496 . 10.1078/S0171-9335(04)70031-X .
• Wilson MD, Riemer C, Martindale DW, Schnupf P, Boright AP, Cheung TL, Hardy DM, Schwartz S, Scherer SW, Tsui LC, Miller W, Koop BF . Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5 . Nucleic Acids Research . 29 . 6 . 1352–65 . Mar 2001 . 11239002 . 29746 . 10.1093/nar/29.6.1352 .
• Wang Y, Gilmore TD . LIM domain protein Trip6 has a conserved nuclear export signal, nuclear targeting sequences, and multiple transactivation domains . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1538 . 2–3 . 260–72 . Apr 2001 . 11336797 . 10.1016/S0167-4889(01)00077-5 . free .
• Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC . Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers . The Journal of Biological Chemistry . 277 . 11 . 9580–9 . Mar 2002 . 11782456 . 10.1074/jbc.M106922200 . free .
• Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA . Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1 . Biology of Reproduction . 68 . 2 . 543–52 . Feb 2003 . 12533418 . 3158802 . 10.1095/biolreprod.102.009076 .
• Xu J, Lai YJ, Lin WC, Lin FT . TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor . The Journal of Biological Chemistry . 279 . 11 . 10459–68 . Mar 2004 . 14688263 . 10.1074/jbc.M311891200 . 3904432 . free .
• Sanz-Rodriguez F, Guerrero-Esteo M, Botella LM, Banville D, Vary CP, Bernabéu C . Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins . The Journal of Biological Chemistry . 279 . 31 . 32858–68 . Jul 2004 . 15148318 . 10.1074/jbc.M400843200 . free . 10261/73323 . free .
• Kassel O, Schneider S, Heilbock C, Litfin M, Göttlicher M, Herrlich P . A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters . Genes & Development . 18 . 20 . 2518–28 . Oct 2004 . 15489293 . 529539 . 10.1101/gad.322404 .
• Li L, Bin LH, Li F, Liu Y, Chen D, Zhai Z, Shu HB . TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways . Journal of Cell Science . 118 . Pt 3 . 555–63 . Feb 2005 . 15657077 . 10.1242/jcs.01641 . 21632160 . free .
• Petit MM, Crombez KR, Vervenne HB, Weyns N, Van de Ven WJ . The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins . FEBS Letters . 579 . 22 . 5061–8 . Sep 2005 . 16137684 . 10.1016/j.febslet.2005.08.012 . 43629118 . free .

Notes and References

1. Yi J, Beckerle MC . The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis . Genomics . 49 . 2 . 314–6 . Apr 1998 . 9598321 . 10.1006/geno.1998.5248 .
2. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD . Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor . Molecular Endocrinology . 9 . 2 . 243–54 . Feb 1995 . 10.1210/mend.9.2.7776974 . 7776974 . free .
3. Web site: Entrez Gene: TRIP6 thyroid hormone receptor interactor 6.
4. Xu J, Lai YJ, Lin WC, Lin FT . TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor . The Journal of Biological Chemistry . 279 . 11 . 10459–68 . Mar 2004 . 14688263 . 10.1074/jbc.M311891200 . 3904432 . free .
5. Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC . Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers . The Journal of Biological Chemistry . 277 . 11 . 9580–9 . Mar 2002 . 11782456 . 10.1074/jbc.M106922200 . free .
6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .