TRIP11 explained

Thyroid receptor-interacting protein 11 is a protein that in humans is encoded by the TRIP11 gene.^{[1] [2] [3]}

Function

TRIP11 was first identified through its ability to interact functionally with thyroid hormone receptor-beta (THRB; MIM 190160). It has also been found in association with the Golgi apparatus and microtubules.[supplied by OMIM]

Interactions

TRIP11 has been shown to interact with Retinoblastoma protein^[4] and Thyroid hormone receptor alpha.^[4]

Further reading

• Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH . A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein . Proceedings of the National Academy of Sciences of the United States of America . 94 . 17 . 9040–5 . Aug 1997 . 9256431 . 23019 . 10.1073/pnas.94.17.9040 . free . 1997PNAS...94.9040C .
• Infante C, Ramos-Morales F, Fedriani C, Bornens M, Rios RM . GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein . The Journal of Cell Biology . 145 . 1 . 83–98 . Apr 1999 . 10189370 . 2148210 . 10.1083/jcb.145.1.83 .
• Ramos-Morales F, Vime C, Bornens M, Fedriani C, Rios RM . Two splice variants of Golgi-microtubule-associated protein of 210 kDa (GMAP-210) differ in their binding to the cis-Golgi network . The Biochemical Journal . 357 . Pt 3 . 699–708 . Aug 2001 . 11463340 . 1221999 . 10.1042/0264-6021:3570699 .
• Pernet-Gallay K, Antony C, Johannes L, Bornens M, Goud B, Rios RM . The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus . Traffic . 3 . 11 . 822–32 . Nov 2002 . 12383348 . 10.1034/j.1600-0854.2002.31107.x . free .
• Beischlag TV, Taylor RT, Rose DW, Yoon D, Chen Y, Lee WH, Rosenfeld MG, Hankinson O . Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia . The Journal of Biological Chemistry . 279 . 52 . 54620–8 . Dec 2004 . 15485806 . 10.1074/jbc.M410456200 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
• Kob R, Baniahmad A, Escher N, von Eggeling F, Melle C . Detection and identification of transcription factors as interaction partners of alien in vivo . Cell Cycle . 6 . 8 . 993–6 . Apr 2007 . 17438371 . 10.4161/cc.6.8.4108 . free .

Notes and References

1. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD . Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor . Molecular Endocrinology . 9 . 2 . 243–54 . Feb 1995 . 10.1210/mend.9.2.7776974 . 7776974 . free .
2. Abe A, Emi N, Tanimoto M, Terasaki H, Marunouchi T, Saito H . Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution . Blood . 90 . 11 . 4271–7 . Dec 1997 . 10.1182/blood.V90.11.4271 . 9373237 . free .
3. Web site: Entrez Gene: TRIP11 thyroid hormone receptor interactor 11.
4. Ming-Jer Tsai . Chang KH, Chen Y, Chen TT, Chou WH, Chen PL, Ma YY, Yang-Feng TL, Leng X, Tsai MJ, O'Malley BW, Lee WH . A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein . Proceedings of the National Academy of Sciences of the United States of America . 94 . 17 . 9040–5 . Aug 1997 . 9256431 . 23019 . 10.1073/pnas.94.17.9040 . free . 1997PNAS...94.9040C .