TRIO (gene) explained

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene.^{[1] [2]}

Interactions

TRIO (gene) has been shown to interact with Filamin^[3] and RHOA.^[4]

Further reading

• Taviaux S, Diriong S, Bellanger JM, Streuli M, Debant A . Assignment of TRIO, the Trio gene (PTPRF interacting) to human chromosome bands 5p 15.1→p 14 by in situ hybridization . Cytogenetics and Cell Genetics . 76 . 1–2 . 107–8 . 1997 . 9154137 . 10.1159/000134524 .
• Liu X, Wang H, Eberstadt M, Schnuchel A, Olejniczak ET, Meadows RP, Schkeryantz JM, Janowick DA, Harlan JE, Harris EA, Staunton DE, Fesik SW . NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio . Cell . 95 . 2 . 269–77 . Oct 1998 . 9790533 . 10.1016/S0092-8674(00)81757-2 . 18146575 . free .
• Seipel K, Medley QG, Kedersha NL, Zhang XA, O'Brien SP, Serra-Pages C, Hemler ME, Streuli M . Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth . Journal of Cell Science . 112 (Pt 12) . 12 . 1825–34 . Jun 1999 . 10.1242/jcs.112.12.1825 . 10341202 .
• Medley QG, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien SP, Streuli M . The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain . The Journal of Biological Chemistry . 275 . 46 . 36116–23 . Nov 2000 . 10948190 . 10.1074/jbc.M003775200 . free .
• Bellanger JM, Astier C, Sardet C, Ohta Y, Stossel TP, Debant A . The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin . Nature Cell Biology . 2 . 12 . 888–92 . Dec 2000 . 11146652 . 10.1038/35046533 . 10182923 .
• Gao Y, Xing J, Streuli M, Leto TL, Zheng Y . Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors . The Journal of Biological Chemistry . 276 . 50 . 47530–41 . Dec 2001 . 11595749 . 10.1074/jbc.M108865200 . free .
• Skowronek KR, Guo F, Zheng Y, Nassar N . The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids . The Journal of Biological Chemistry . 279 . 36 . 37895–907 . Sep 2004 . 15199069 . 10.1074/jbc.M312677200 . free .
• Zheng M, Simon R, Mirlacher M, Maurer R, Gasser T, Forster T, Diener PA, Mihatsch MJ, Sauter G, Schraml P . TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer . The American Journal of Pathology . 165 . 1 . 63–9 . Jul 2004 . 15215162 . 1618551 . 10.1016/S0002-9440(10)63275-0 .
• Yoshizuka N, Moriuchi R, Mori T, Yamada K, Hasegawa S, Maeda T, Shimada T, Yamada Y, Kamihira S, Tomonaga M, Katamine S . An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential . The Journal of Biological Chemistry . 279 . 42 . 43998–4004 . Oct 2004 . 15308664 . 10.1074/jbc.M406082200 . free .
• Portales-Casamar E, Briançon-Marjollet A, Fromont S, Triboulet R, Debant A . Identification of novel neuronal isoforms of the Rho-GEF Trio . Biology of the Cell . 98 . 3 . 183–93 . Mar 2006 . 16033331 . 10.1042/BC20050009 . 24166861 . free .
• Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R . Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry . Nature Methods . 2 . 8 . 591–8 . Aug 2005 . 16094384 . 10.1038/nmeth776 . 20475874 .
• Adamowicz M, Radlwimmer B, Rieker RJ, Mertens D, Schwarzbach M, Schraml P, Benner A, Lichter P, Mechtersheimer G, Joos S . Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas . Genes, Chromosomes & Cancer . 45 . 9 . 829–38 . Sep 2006 . 16752383 . 10.1002/gcc.20343 . 24491021 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Chhatriwala MK, Betts L, Worthylake DK, Sondek J . The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation . Journal of Molecular Biology . 368 . 5 . 1307–20 . May 2007 . 17391702 . 1890047 . 10.1016/j.jmb.2007.02.060 .
• Rojas RJ, Yohe ME, Gershburg S, Kawano T, Kozasa T, Sondek J . Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain . The Journal of Biological Chemistry . 282 . 40 . 29201–10 . Oct 2007 . 17606614 . 2655113 . 10.1074/jbc.M703458200 . free .

Notes and References

1. Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M . The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains . Proceedings of the National Academy of Sciences of the United States of America . 93 . 11 . 5466–71 . May 1996 . 8643598 . 39269 . 10.1073/pnas.93.11.5466 . 1996PNAS...93.5466D . free .
2. Web site: Entrez Gene: TRIO triple functional domain (PTPRF interacting).
3. Bellanger JM, Astier C, Sardet C, Ohta Y, Stossel TP, Debant A . The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin . Nature Cell Biology . 2 . 12 . 888–92 . Dec 2000 . 11146652 . 10.1038/35046533 . 10182923 .
4. Medley QG, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien SP, Streuli M . The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain . The Journal of Biological Chemistry . 275 . 46 . 36116–23 . Nov 2000 . 10948190 . 10.1074/jbc.M003775200 . free .