TRIM3 explained

Tripartite motif-containing protein 3 is a protein that in humans is encoded by the TRIM3 gene.^{[1] [2]}

The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.

Interactions

TRIM3 has been shown to interact with Actinin alpha 4.^[3]

TRIM3 binds to and ubiquitinates Estrogen receptor alpha (ERa) leading to receptor's stabilization.^[4]

Moreover, TRIM3 interacts with P53 which promotes the formation of K48-linked poly-ubiquitin chains and degradation.^[5]

Further reading

• El-Husseini AE, Kwasnicka D, Yamada T, Hirohashi S, Vincent SR . BERP, a novel ring finger protein, binds to alpha-actinin-4 . Biochemical and Biophysical Research Communications . 267 . 3 . 906–911 . January 2000 . 10673389 . 10.1006/bbrc.1999.2045 .
• El-Husseini AE, Fretier P, Vincent SR . Cloning and characterization of a gene (RNF22) encoding a novel brain expressed ring finger protein (BERP) that maps to human chromosome 11p15.5 . Genomics . 71 . 3 . 363–367 . February 2001 . 11170753 . 10.1006/geno.2000.6452 .
• Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A . 6 . The tripartite motif family identifies cell compartments . The EMBO Journal . 20 . 9 . 2140–2151 . May 2001 . 11331580 . 125245 . 10.1093/emboj/20.9.2140 .
• Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S . E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme . FEBS Letters . 503 . 1 . 61–64 . August 2001 . 11513855 . 10.1016/S0014-5793(01)02689-8 . 42977319 . free .
• Yan Q, Sun W, Kujala P, Lotfi Y, Vida TA, Bean AJ . CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling . Molecular Biology of the Cell . 16 . 5 . 2470–2482 . May 2005 . 15772161 . 1087250 . 10.1091/mbc.E04-11-1014 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . November 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. El-Husseini AE, Vincent SR . Cloning and characterization of a novel RING finger protein that interacts with class V myosins . The Journal of Biological Chemistry . 274 . 28 . 19771–19777 . July 1999 . 10391919 . 10.1074/jbc.274.28.19771 . free .
2. Web site: Entrez Gene: TRIM3 tripartite motif-containing 3.
3. El-Husseini AE, Kwasnicka D, Yamada T, Hirohashi S, Vincent SR . BERP, a novel ring finger protein, binds to alpha-actinin-4 . Biochemical and Biophysical Research Communications . 267 . 3 . 906–911 . January 2000 . 10673389 . 10.1006/bbrc.1999.2045 .
4. Zhuang T, Wang B, Tan X, Wu L, Li X, Li Z, Cai Y, Fan R, Yang X, Zhang C, Xia Y, Niu Z, Liu B, Cao Q, Ding Y, Zhou Z, Huang Q, Yang H . 6 . TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression . Cell Communication and Signaling . 20 . 1 . 45 . April 2022 . 35392925 . 8991925 . 10.1186/s12964-022-00861-z . free .
5. Wang X, Zhang Y, Pei X, Guo G, Xue B, Duan X, Dou D . TRIM3 inhibits P53 signaling in breast cancer cells . Cancer Cell International . 20 . 1 . 559 . November 2020 . 33292295 . 7685606 . 10.1186/s12935-020-01630-z . free .