TRIM15 explained

Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene.^{[1] [2] [3]}

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[4]

Further reading

• Shiina T, Ota M, Shimizu S, etal . Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity . Genetics . 173 . 3 . 1555–70 . 2006 . 16702430 . 10.1534/genetics.106.057034 . 1526686 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Harada H, Harada Y, O'Brien DP, etal . HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells . Mol. Cell. Biol. . 19 . 5 . 3808–15 . 1999 . 10207104 . 10.1128/MCB.19.5.3808. 84222 .

Notes and References

1. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A . The tripartite motif family identifies cell compartments . EMBO J . 20 . 9 . 2140–51 . May 2001 . 11331580 . 125245 . 10.1093/emboj/20.9.2140 .
2. Goei VL, Parimoo S, Capossela A, Chu TW, Gruen JR . Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection . Am J Hum Genet . 54 . 2 . 244–51 . Mar 1994 . 8304341 . 1918154 .
3. Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM . A transcription map of the major histocompatibility complex (MHC) class I region . Genomics . 36 . 1 . 70–85 . Feb 1997 . 8812418 . 10.1006/geno.1996.0427 . free .
4. Web site: Entrez Gene: TRIM15 tripartite motif-containing 15.