TRIL (gene) explained

KIAA0644, also known as TRIL or TLR4 interactor with leucine rich repeats, is a protein that in humans is encoded by the KIAA0644 gene.^[1]

Function

The exact function of KIAA0644 is not known. It is, however, a member of the leucine-rich repeat family of proteins, which are known to be involved in protein-protein interactions. This protein is known to interact with the TLR4 protein.

TRIL is a component of the TLR4 complex and is induced in a number of cell types by lipopolysaccharide (LPS).^[2]

Protein sequence

The main isoform of the human protein is 811 amino long and is composed primarily of leucine (17%), alanine and arginine (~10%), and glycine (~ 8.5%) residues. The protein sequence is predicted to consists mostly of α-helices and a few β-sheet

Homology

KIAA0644 is conserved well among mammals but can be found in all chordates with lower sequence identities.

Gene neighborhood

The KIAA0644 gene is neighbors to mRNA-cAMP responsive element binding gene downstream and mRNA carboxypeptidase and serine carboxypeptidase gene upstream ^{[3] [4]}

Further reading

• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2002 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–772 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S .
• Büssow K, Cahill D, Nietfeld W, etal . A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library . Nucleic Acids Res. . 26 . 21 . 5007–5008 . 1998 . 9776767 . 147919 . 10.1093/nar/26.21.5007.
• Wheeler HE, Metter EJ, Tanaka T, etal . Sequential Use of Transcriptional Profiling, Expression Quantitative Trait Mapping, and Gene Association Implicates MMP20 in Human Kidney Aging . PLOS Genet. . 5 . 10 . e1000685 . 2009 . 19834535 . 2752811 . 10.1371/journal.pgen.1000685 . Gibson . Greg . free .

Notes and References

1. Web site: Entrez Gene: TRIL TLR4 interactor with leucine rich repeats. 13 May 2010.
2. Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA . TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain . J. Immunol. . 183 . 6 . 3989–3995 . September 2009 . 19710467 . 10.4049/jimmunol.0901518 . free .
3. Web site: NCBI Entrez. 13 May 2010.
4. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res. . 5 . 3 . 169–176 . June 1998 . 9734811 . 10.1093/dnares/5.3.169. free .