TRHDE explained

Thyrotropin releasing hormone degrading enzyme is a protein, specifically a pyroglutamyl-peptidase II enzyme, that in humans is encoded by the TRHDE gene.^[1]

Function

This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.

Further reading

• Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D . Vimentin is a novel AKT1 target mediating motility and invasion . Oncogene . 30 . 4 . 457–70 . January 2011 . 20856200 . 3010301 . 10.1038/onc.2010.421 .
• Bödeker H, Keim V, Fiedler F, Dagorn JC, Iovanna JL . PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha . Molecular Cell Biology Research Communications . 2 . 3 . 150–4 . 1999 . 10662590 . 10.1006/mcbr.1999.0166 .
• Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB . Chemerin, a novel adipokine in the regulation of angiogenesis . The Journal of Clinical Endocrinology and Metabolism . 95 . 5 . 2476–85 . May 2010 . 20237162 . 2869547 . 10.1210/jc.2010-0042 .
• Freudenberg J, Lee HS, Han BG, Shin HD, Kang YM, Sung YK, Shim SC, Choi CB, Lee AT, Gregersen PK, Bae SC . Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci . Arthritis and Rheumatism . 63 . 4 . 884–93 . April 2011 . 21452313 . 10.1002/art.30235 .
• Schomburg L, Turwitt S, Prescher G, Lohmann D, Horsthemke B, Bauer K . Human TRH-degrading ectoenzyme cDNA cloning, functional expression, genomic structure and chromosomal assignment . European Journal of Biochemistry . 265 . 1 . 415–22 . October 1999 . 10491199 . 10.1046/j.1432-1327.1999.00753.x .

Notes and References

1. Web site: TRHDE thyrotropin releasing hormone degrading enzyme [Homo sapiens (human) ] ].