TRERF1 explained

Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.^{[1] [2]}

This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.^[3]

Interactions

TRERF1 has been shown to interact with Steroidogenic factor 1,^[4] EP300 and CREB-binding protein.^[1]

Further reading

• Dorssers LC, Veldscholte J . Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells . International Journal of Cancer . 72 . 4 . 700–5 . August 1997 . 9259413 . 10.1002/(SICI)1097-0215(19970807)72:4<700::AID-IJC24>3.0.CO;2-D . 29607511 . free .
• Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW . The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells . The Journal of Biological Chemistry . 277 . 42 . 39144–55 . October 2002 . 12101186 . 10.1074/jbc.M205786200 . free .
• Gizard F, El-Alfy M, Duguay Y, Lavallée B, DeWitte F, Staels B, Beatty BG, Hum DW . 6 . Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression . Endocrine Research . 28 . 4 . 559–74 . November 2002 . 12530663 . 10.1081/ERC-120016841 . 22485023 .
• Gizard F, Teissier E, Dufort I, Luc G, Luu-The V, Staels B, Hum DW . The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells . Journal of Molecular Endocrinology . 32 . 2 . 557–69 . April 2004 . 15072559 . 10.1677/jme.0.0320557 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . 6 . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . August 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Gizard F, Robillard R, Barbier O, Quatannens B, Faucompré A, Révillion F, Peyrat JP, Staels B, Hum DW . 6 . TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1 . Molecular and Cellular Biology . 25 . 11 . 4335–48 . June 2005 . 15899840 . 1140623 . 10.1128/MCB.25.11.4335-4348.2005 .
• Gizard F, Robillard R, Gross B, Barbier O, Révillion F, Peyrat JP, Torpier G, Hum DW, Staels B . 6 . TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone . Molecular and Cellular Biology . 26 . 20 . 7632–44 . October 2006 . 17015480 . 1636875 . 10.1128/MCB.00326-06 .

Notes and References

1. Gizard F, Lavallée B, DeWitte F, Hum DW . A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression . The Journal of Biological Chemistry . 276 . 36 . 33881–92 . September 2001 . 11349124 . 10.1074/jbc.M100113200 . free .
2. Web site: Entrez Gene: TRERF1 transcriptional regulating factor 1.
3. Web site: Entrez Gene: TRERF1 transcriptional regulating factor 1.
4. Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW . The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells . The Journal of Biological Chemistry . 277 . 42 . 39144–55 . October 2002 . 12101186 . 10.1074/jbc.M205786200 . free .