TREAT-NMD explained

TREAT-NMD (treat NeuroMuscular Disease) is a global academic network that focuses on advancing research in neuromuscular disorders.^[1] It was established in 2007 with its coordination centre at the Newcastle University.^[2] As of 2018, the network comprises over a hundred research centres and patient organisations from 54 countries^[3] as well as independent academics and patient representatives.^[4] The network's aim is to provide infrastructure to accelerating research through supporting collaboration between its members.^[5] Its main goals include improving trial-readiness worldwide, advancing patient diagnosis and care and accelerating pre-clinical research.^{[6] [7]}

Through patient registries, TREAT-NMD provides genotype–phenotype correlation between genetic mutations and neuromuscular disease burden.^[8]

Further reading

• Heslop . Emma . Csimma . Cristina . Straub . Volker . McCall . John . Nagaraju . Kanneboyina . Wagner . Kathryn R. . Caizergues . Didier . Korinthenberg . Rudolf . Flanigan . Kevin M. . 2015-04-23 . The TREAT-NMD advisory committee for therapeutics (TACT): an innovative de-risking model to foster orphan drug development . Orphanet Journal of Rare Diseases . 10 . 1 . 49 . 10.1186/s13023-015-0258-1 . 4417237 . 25902795 . free .
• Bladen . Catherine L. . Rafferty . Karen . Straub . Volker . Monges . Soledad . Moresco . Angélica . Dawkins . Hugh . Roy . Anna . Chamova . Teodora . Guergueltcheva . Velina . 2013-08-26 . The TREAT-NMD Duchenne Muscular Dystrophy Registries: Conception, Design, and Utilization by Industry and Academia . Human Mutation . 34 . 11 . 1449–1457 . 23913485 . 10.1002/humu.22390 . 38772058 . free .
• Aartsma-Rus . Annemieke . Mercuri . Eugenio . Vroom . Elizabeth . Balabanov . Pavel . Meeting report of the "Regulatory Exchange Matters" session at the 5th International TREAT-NMD Conference:: Lessons in communication: How an early dialogue between patients, regulators and academics can further therapy development for neuromuscular disorders Freiburg, Germany, 27-29 November 2017 . Neuromuscular Disorders . 28. 7. 619–623. April 2018 . 29778308 . 10.1016/j.nmd.2018.04.009 . free .

Notes and References

1. Leary . Rebecca . Oyewole . Anne . Bushby . Katharine . Aartsma-Rus . Annemieke . 2017-07-06 . Translational Research in Europe for the Assessment and Treatment for Neuromuscular Disorders (TREAT-NMD) . Neuropediatrics . 48 . 4 . 211–220 . 28683502 . 10.1055/s-0037-1604110 . 19283049 .
2. Katharine . Bushby . Stephen . Lynn . Volker . Straub . Bushby K, Lynn S, Straub T --> . Collaborating to bring new therapies to the patient--the TREAT-NMD model . Acta Myologica . 28 . 1 . 12–5 . July 2009 . 19772190 . 2859629 .
3. Web site: TREAT-NMD Alliance Members – Organizations . TREAT Neuromuscular Network . 2018-06-13.
4. Web site: TREAT-NMD Alliance Members – Individuals . TREAT Neuromuscular Network . 2018-06-13.
5. Web site: TREAT-NMD : About the TREAT-NMD network . TREAT Neuromuscular Network .
6. Raffaella . Willmann . Markus A. . Rüegg . Rebecca J. . Fairclough . Kay E . Davies . Stefanie . Possekel . Thomas . Meier . Willmann R, Rüegg MA, Fairclough R, Davies KE, Possekel S, Meier T --> . T.P.3.03 TREAT-NMD-Activity 7: Accelerate preclinical phase of new therapeutic treatment development . Neuromuscular Disorders . October 2008 . 18 . 9–10 . 794 . 10.1016/j.nmd.2008.06.242 . 54330245 . Conference abstract.
7. Eugenio Maria . Mercuri . Anna G . Mayhew . Francesco . Muntoni . Volker . Straub . Gert-Jan . Van Ommen . Thomas . Voit . Enrico . Bertini . Katherine . Bushby . Mercuri E, Mayhew A, Muntoni F, Messina S, Straub V, Van Ommen GJ, Voit T, Bertini E, Bushby K --> . Towards harmonisation of outcome measures for DMD and SMA within TREAT-NMD; report of three expert workshops: TREAT-NMD/ENMC workshop on outcome measures, 12th--13th May 2007, Naarden, The Netherlands; TREAT-NMD workshop on outcome measures in experimental trials for DMD, 30th June--1st July 2007, Naarden, The Netherlands; conjoint Institute of Myology TREAT-NMD meeting on physical activity monitoring in neuromuscular disorders, 11th July 2007, Paris, France . Neuromuscular Disorders . 18 . 11 . 894–903 . November 2008 . 18818076 . 10.1016/j.nmd.2008.07.003 . Workshop report . free .
8. Book: Thompson R, Robertson A, Lochmüller H . Rare Diseases Epidemiology: Update and Overview . Natural History, Trial Readiness and Gene Discovery: Advances in Patient Registries for Neuromuscular Disease . Advances in Experimental Medicine and Biology . 1031 . 97–124 . 2017 . 29214567 . 10.1007/978-3-319-67144-4_5 . 978-3-319-67142-0 .