TRAPPC10 explained

Trafficking protein particle complex subunit 10 is a protein that in humans is encoded by the TRAPPC10 gene.^{[1] [2]}

The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi.

Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Nagamine K . Isolation of cDNA for a novel human protein KNP-I that is homologous to the E. coli SCRP-27A protein from the autoimmune polyglandular disease type I (APECED) region of chromosome 21q22.3 . Biochem. Biophys. Res. Commun. . 225 . 2 . 608–16 . 1996 . 8753807 . 10.1006/bbrc.1996.1218 . vanc. Kudoh J . Minoshima S . 3 . Kawasaki . Kazuhiko . Asakawa . Shuichi . Ito . Fumiaki . Shimizu . Nobuyoshi .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Nagamine K . Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3 . Biochem. Biophys. Res. Commun. . 235 . 1 . 185–90 . 1997 . 9196060 . 10.1006/bbrc.1997.6758 . vanc. Kudoh J . Kawasaki K . 3 . Minoshima . Shinsei . Asakawa . Shuichi . Ito . Fumiaki . Shimizu . Nobuyoshi .
• Nagamine K . Genomic organization and complete nucleotide sequence of the human PWP2 gene on chromosome 21 . Genomics . 42 . 3 . 528–31 . 1997 . 9205129 . 10.1006/geno.1997.4761 . vanc. Kudoh J . Minoshima S . 3 . Kawasaki . Kazuhiko . Asakawa . Shuichi . Ito . Fumiaki . Shimizu . Nobuyoshi .
• Lafrenière RG . Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3 . Gene . 198 . 1–2 . 313–21 . 1997 . 9370297 . 10.1016/S0378-1119(97)00333-8 . vanc. Kibar Z . Rochefort DL . 3 . Fei-Yu Han . Fon . Edward A. . Dubé . Marie-Pierre . Kang . Xiaolin . Baird . Stephen . Korneluk . Robert G. . FY .
• Hattori M . The DNA sequence of human chromosome 21 . Nature . 405 . 6784 . 311–9 . 2000 . 10830953 . 10.1038/35012518 . vanc. Fujiyama A . Taylor TD . 3 . Taylor . T. D. . Watanabe . H. . Yada . T. . Park . H.-S. . Toyoda . A. . Ishii . K. . 2000Natur.405..311H . free .
• Gavin AC . Functional organization of the yeast proteome by systematic analysis of protein complexes . Nature . 415 . 6868 . 141–7 . 2002 . 11805826 . 10.1038/415141a . vanc. Bösche M . Krause R . 3 . Grandi . Paola . Marzioch . Martina . Bauer . Andreas . Schultz . Jörg . Rick . Jens M. . Michon . Anne-Marie . 2002Natur.415..141G . 4425555 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . vanc. Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .

Notes and References

1. Yamakawa K, Mitchell S, Hubert R, Chen XN, Colbern S, Huo YK, Gadomski C, Kim UJ, Korenberg JR . Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3 . Hum Mol Genet . 4 . 4 . 709–16 . Sep 1995 . 7633421 . 10.1093/hmg/4.4.709 .
2. Web site: Entrez Gene: TMEM1 transmembrane protein 1.