TRAP1 explained

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.^{[1] [2] [3]}

Interactions

TRAP1 has been shown to interact with EXT2,^[4] EXT1^[4] and Retinoblastoma protein.^[5]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Chen CF . A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock . Mol. Cell. Biol. . 16 . 9 . 4691–9 . 1996 . 8756626 . 10.1128/MCB.16.9.4691. 231469 . vanc. Chen Y . Dai K . 3 . Chen . PL . Riley . DJ . Lee . WH .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Charng MJ, Zhang D, Kinnunen P, Schneider MD . A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor . J. Biol. Chem. . 273 . 16 . 9365–8 . 1998 . 9545258 . 10.1074/jbc.273.16.9365 . free .
• Simmons AD . A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses . Hum. Mol. Genet. . 8 . 12 . 2155–64 . 1999 . 10545594 . 10.1093/hmg/8.12.2155 . vanc. Musy MM . Lopes CS . 3 . Hwang . LY . Yang . YP . Lovett . M . free .
• Wurthner JU . Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone . J. Biol. Chem. . 276 . 22 . 19495–502 . 2001 . 11278302 . 10.1074/jbc.M006473200 . vanc. Frank DB . Felici A . 3 . Green . HM . Cao . Z . Schneider . MD . McNally . JG . Lechleider . RJ . Roberts . AB . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Masuda Y . Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin . J. Biol. Chem. . 279 . 41 . 42503–15 . 2004 . 15292218 . 10.1074/jbc.M404256200 . vanc. Shima G . Aiuchi T . 3 . Horie . M . Hori . K . Nakajo . S . Kajimoto . S . Shibayama-Imazu . T . Nakaya . K . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Brown V . Binding specificity of Toll-like receptor cytoplasmic domains . Eur. J. Immunol. . 36 . 3 . 742–53 . 2006 . 16482509 . 10.1002/eji.200535158 . 2762736 . vanc. Brown RA . Ozinsky A . 3 . Hesselberth . Jay R. . Fields . Stanley .
• Im CN, Lee JS, Zheng Y, Seo JS . Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species . J. Cell. Biochem. . 100 . 2 . 474–86 . 2007 . 16927372 . 10.1002/jcb.21064 . 12489077 .

Notes and References

1. Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO . The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties . J Biol Chem . 275 . 5 . 3305–12 . March 2000 . 10652318 . 10.1074/jbc.275.5.3305 . free .
2. Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB . Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor . J Biol Chem . 270 . 8 . 3574–81 . March 1995 . 7876093 . 10.1074/jbc.270.8.3574 . free .
3. Web site: Entrez Gene: TRAP1 TNF receptor-associated protein 1.
4. Simmons . A D . Musy M M . Lopes C S . Hwang L Y . Yang Y P . Lovett M . November 1999 . A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses . Hum. Mol. Genet. . 8 . 12 . 2155–64 . 0964-6906. 10545594 . 10.1093/hmg/8.12.2155 . free .
5. Chen . C F . Chen Y . Dai K . Chen P L . Riley D J . Lee W H . September 1996 . A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock . Mol. Cell. Biol. . 16 . 9 . 4691–9 . 0270-7306. 8756626 . 231469 . 10.1128/MCB.16.9.4691 .