TRANK1 explained

Tetratricopeptide repeat and ankyrin repeat containing 1 is a protein that in humans is encoded by the TRANK1 gene.^[1]

Disease Linkage

Through a Genome-wide association study, TRANK1 has been relationed with the Bipolar disorder.^[2]

Further reading

• Goes FS, Hamshere ML, Seifuddin F, Pirooznia M, Belmonte-Mahon P, Breuer R, Schulze T, Nöthen M, Cichon S, Rietschel M, Holmans P, Zandi PP, Craddock N, Potash JB . 6 . Genome-wide association of mood-incongruent psychotic bipolar disorder . Translational Psychiatry . 2 . 10 . e180 . October 2012 . 23092984 . 3565814 . 10.1038/tp.2012.106 .
• Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, Kassem L, Park JH, Chatterjee N, Jamain S, Cheng A, Leboyer M, Muglia P, Schulze TG, Cichon S, Nöthen MM, Rietschel M, McMahon FJ, Farmer A, McGuffin P, Craig I, Lewis C, Hosang G, Cohen-Woods S, Vincent JB, Kennedy JL, Strauss J . 6 . Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder . Molecular Psychiatry . 18 . 2 . 195–205 . February 2013 . 22182935 . 10.1038/mp.2011.157 . free .

Notes and References

1. Web site: Entrez Gene: Tetratricopeptide repeat and ankyrin repeat containing 1 .
2. Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Forstner AJ, Schumacher J, Breuer R, Meier S, Herms S, Hoffmann P, Lacour A, Witt SH, Reif A, Müller-Myhsok B, Lucae S, Maier W, Schwarz M, Vedder H, Kammerer-Ciernioch J, Pfennig A, Bauer M, Hautzinger M, Moebus S, Priebe L, Czerski PM, Hauser J, Lissowska J, Szeszenia-Dabrowska N, Brennan P, McKay JD, Wright A, Mitchell PB, Fullerton JM, Schofield PR, Montgomery GW, Medland SE, Gordon SD, Martin NG, Krasnow V, Chuchalin A, Babadjanova G, Pantelejeva G, Abramova LI, Tiganov AS, Polonikov A, Khusnutdinova E, Alda M, Grof P, Rouleau GA, Turecki G, Laprise C, Rivas F, Mayoral F, Kogevinas M, Grigoroiu-Serbanescu M, Propping P, Becker T, Rietschel M, Nöthen MM, Cichon S . 6 . Genome-wide association study reveals two new risk loci for bipolar disorder . Nature Communications . 5 . 3339 . March 2014 . 24618891 . 10.1038/ncomms4339 . 2014NatCo...5.3339M . free . 1959.4/unsworks_13067 . free .