TRAM2 explained
Translocating chain-associated membrane protein 2 is a protein that in humans is encoded by the TRAM2 gene.[1] [2] [3]
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[4]
Further reading
- Sudo K, Chinen K, Nakamura Y . 2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library. . Genomics . 24 . 2 . 276–9 . 1995 . 7698749 . 10.1006/geno.1994.1616 .
- Hillier LD, Lennon G, Becker M, etal . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . 2003Natur.425..805M . free .
- Hsu LC, Liu S, Abedinpour F, etal . The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. . Mol. Cell. Biol. . 23 . 23 . 8773–85 . 2003 . 14612417 . 10.1128/MCB.23.23.8773-8785.2003 . 262660 .
- Stefanovic B, Stefanovic L, Schnabl B, etal . TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. . Mol. Cell. Biol. . 24 . 4 . 1758–68 . 2004 . 14749390 . 10.1128/MCB.24.4.1758-1768.2004 . 344171 .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
Notes and References
- Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S . Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res . 1 . 5 . 223–9 . Dec 1995 . 7584044 . 10.1093/dnares/1.5.223 . free .
- Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM . Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene . Mamm Genome . 10 . 12 . 1175–8 . Jan 2000 . 10594243 . 10.1007/s003359901186 . 11705244 .
- Web site: Entrez Gene: TRAM2 translocation associated membrane protein 2.
- Web site: Entrez Gene: TRAM2 translocation associated membrane protein 2.