TRAK2 explained

Trafficking kinesin-binding protein 2 is a protein that in humans is encoded by the TRAK2 gene.^{[1] [2] [3]}

Interactions

TRAK2 has been shown to interact with Kir2.1^[4] and GABRB2.^[5]

Further reading

• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Research . 5 . 1 . 31–9 . Feb 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
• Machado RD, Pauciulo MW, Fretwell N, Veal C, Thomson JR, Vilariño Güell C, Aldred M, Brannon CA, Trembath RC, Nichols WC . A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium . Genomics . 68 . 2 . 220–8 . Sep 2000 . 10964520 . 10.1006/geno.2000.6291 .
• Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA . Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1 . The Journal of Biological Chemistry . 277 . 33 . 30079–90 . Aug 2002 . 12034717 . 10.1074/jbc.M200438200 . free .
• Iyer SP, Akimoto Y, Hart GW . Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase . The Journal of Biological Chemistry . 278 . 7 . 5399–409 . Feb 2003 . 12435728 . 10.1074/jbc.M209384200 . free .
• Brickley K, Smith MJ, Beck M, Stephenson FA . GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin . The Journal of Biological Chemistry . 280 . 15 . 14723–32 . Apr 2005 . 15644324 . 10.1074/jbc.M409095200 . free .
• Fransson S, Ruusala A, Aspenström P . The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking . Biochemical and Biophysical Research Communications . 344 . 2 . 500–10 . Jun 2006 . 16630562 . 10.1016/j.bbrc.2006.03.163 .
• Smith MJ, Pozo K, Brickley K, Stephenson FA . Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes . The Journal of Biological Chemistry . 281 . 37 . 27216–28 . Sep 2006 . 16835241 . 10.1074/jbc.M600522200 . free .
• Grishin A, Li H, Levitan ES, Zaks-Makhina E . Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1 . The Journal of Biological Chemistry . 281 . 40 . 30104–11 . Oct 2006 . 16895905 . 10.1074/jbc.M602439200 . free .

Notes and References

1. Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR . Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2 . Genomics . 71 . 2 . 200–13 . Jan 2001 . 11161814 . 10.1006/geno.2000.6392 .
2. Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT . Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice . Nature Genetics . 38 . 2 . 245–50 . Feb 2006 . 16380713 . 10.1038/ng1715 . 20231963 .
3. Web site: Entrez Gene: TRAK2 trafficking protein, kinesin binding 2.
4. Grishin A, Li H, Levitan ES, Zaks-Makhina E . Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1 . The Journal of Biological Chemistry . 281 . 40 . 30104–11 . Oct 2006 . 16895905 . 10.1074/jbc.M602439200 . free .
5. Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA . Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1 . The Journal of Biological Chemistry . 277 . 33 . 30079–90 . Aug 2002 . 12034717 . 10.1074/jbc.M200438200 . free .