TRA2A explained

Transformer-2 protein homolog alpha is a protein that in humans is encoded by the TRA2A gene.^{[1] [2] [3]}

This gene is a member of the transformer 2 homolog family and encodes a protein with two RS domains and an RRM (RNA recognition motif) domain. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Several alternatively spliced transcript variants of this gene have been described; however, the full-length nature of some of these variants has not been determined.^[3]

Further reading

• Toward a complete human genome sequence. . Genome Res. . 8 . 11 . 1097–108 . 1999 . 9847074 . 10.1101/gr.8.11.1097. Sanger Centre . The . Washington University Genome Sequencing Cente . The . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Matsuda A, Suzuki Y, Honda G, etal . Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. . Oncogene . 22 . 21 . 3307–18 . 2003 . 12761501 . 10.1038/sj.onc.1206406 . free .
• Shin C, Feng Y, Manley JL . Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. . Nature . 427 . 6974 . 553–8 . 2004 . 14765198 . 10.1038/nature02288 . 2004Natur.427..553S . 4423246 .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Gevaert K, Staes A, Van Damme J, etal . Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. . Proteomics . 5 . 14 . 3589–99 . 2006 . 16097034 . 10.1002/pmic.200401217 . 895879 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Dauwalder B, Amaya-Manzanares F, Mattox W . A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions . Proc Natl Acad Sci U S A . 93 . 17 . 9004–9 . Oct 1996 . 8799144 . 38585 . 10.1073/pnas.93.17.9004 . free . 1996PNAS...93.9004D .
2. Tacke R, Tohyama M, Ogawa S, Manley JL . Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing . Cell . 93 . 1 . 139–48 . May 1998 . 9546399 . 10.1016/S0092-8674(00)81153-8 . 15384749 . free .
3. Web site: Entrez Gene: TRA2A transformer-2 alpha.