TPTE explained

Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTE gene.^{[1] [2]}

Function

TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.^[2] TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipid phosphatase;^[3] TPTE itself is predicted to lack phosphatase activity.^[4] TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.

Further reading

• Antonarakis SE . 10 years of Genomics, chromosome 21, and Down syndrome. . Genomics . 51 . 1 . 1–16 . 1998 . 9693027 . 10.1006/geno.1998.5335 .
• Chen H, Rossier C, Morris MA, etal . A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y. . Hum. Genet. . 105 . 5 . 399–409 . 2000 . 10598804 . 10.1007/s004390051122 .
• Guipponi M, Yaspo ML, Riesselman L, etal . Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21. . Hum. Genet. . 107 . 2 . 127–31 . 2000 . 11030409 . 10.1007/s004390000343 . 29304641 .
• Wu Y, Dowbenko D, Pisabarro MT, etal . PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase. . J. Biol. Chem. . 276 . 24 . 21745–53 . 2001 . 11279206 . 10.1074/jbc.M101480200 . free .
• Guipponi M, Tapparel C, Jousson O, etal . The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family. . Hum. Genet. . 109 . 6 . 569–75 . 2002 . 11810268 . 10.1007/s004390100607 . 8267495 .

Notes and References

1. Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE . The TPTE gene family: cellular expression, subcellular localization and alternative splicing . Gene . 323 . 189–99 . Dec 2003 . 14659893 . 10.1016/j.gene.2003.09.038 .
2. Web site: Entrez Gene: TPTE transmembrane phosphatase with tensin homology.
3. Leslie NR, Yang X, Downes CP, Weijer CJ . PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration . Curr. Biol. . 17 . 2 . 115–25 . January 2007 . 17240336 . 1885949 . 10.1016/j.cub.2006.12.026 .
4. Chen. Mark J.. Dixon. Jack E.. Manning. Gerard. 2017-04-11. Genomics and evolution of protein phosphatases. Sci. Signal.. en. 10. 474. eaag1796. 10.1126/scisignal.aag1796. 1945-0877. 28400531. 41041971.