TPD52L2 explained

Tumor protein D54 is a protein that in humans is encoded by the TPD52L2 gene.^{[1] [2]}

Interactions

TPD52L2 has been shown to interact with TPD52L1 and TPD52.^[1]

Cellular function

TPD52L2 has a role in membrane traffic.^[3] TPD52L2 is found on small transport vesicles, termed intracellular nanovesicles, that transfer proteins between different cellular compartments. When TPD52L2 is depleted from HeLa cells, the following trafficking pathways are impaired: anterograde traffic, recycling of cargo and Golgi integrity.^[3] Proteomic analysis indicates that TPD52L2 is one of the most abundant proteins expressed in HeLa cells.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Byrne JA, Mattei MG, Basset P . Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52) . Genomics . 35 . 3 . 523–32 . 1996 . 8812487 . 10.1006/geno.1996.0393 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Nourse CR, Mattei MG, Gunning P, Byrne JA . Cloning of a third member of the D52 gene family indicates alternative coding sequence usage in D52-like transcripts . Biochim. Biophys. Acta . 1443 . 1–2 . 155–68 . 1998 . 9838088 . 10.1016/S0167-4781(98)00211-5 .
• Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA . Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system . Genomics . 76 . 1–3 . 81–8 . 2001 . 11549320 . 10.1006/geno.2001.6610 .
• Boutros R, Byrne JA . D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells . Exp. Cell Res. . 310 . 1 . 152–65 . 2005 . 16112108 . 10.1016/j.yexcr.2005.07.009 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Barbaric D, Byth K, Dalla-Pozza L, Byrne JA . Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations . Leuk. Res. . 30 . 11 . 1355–63 . 2006 . 16620967 . 10.1016/j.leukres.2006.03.009 .
• Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J . A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins . Biochem. Biophys. Res. Commun. . 344 . 3 . 798–806 . 2006 . 16631610 . 10.1016/j.bbrc.2006.03.208 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Byrne JA, Nourse CR, Basset P, Gunning P . Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system . Oncogene . 16 . 7 . 873–81 . Mar 1998 . 9484778 . 10.1038/sj.onc.1201604 . 9948136 .
2. Web site: Entrez Gene: TPD52L2 tumor protein D52-like 2.
3. Larocque G, La-Borde PJ, Clarke NI, Carter NJ, Royle SJ . Tumor protein D54 defines a new class of intracellular transport vesicle . J Cell Biol . 219. 2019 . 1 . 31672706 . 10.1083/jcb.201812044 . 7039206 . free .
4. Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M . A human interactome in three quantitative dimensions organized by stoichiometries and abundances . Cell . 163 . 3 . 712–23 . 2017 . 26496610 . 10.1016/j.cell.2015.09.053 . free .