TPD52 explained

Tumor protein D52 is a protein that in humans is encoded by the TPD52 gene.^{[1] [2]}

Interactions

TPD52 has been shown to interact with TPD52L2,^[3] TPD52L1^[3] and MAL2.^[4]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Chen SL, Maroulakou IG, Green JE, Romano-Spica V, Modi W, Lautenberger J, Bhat NK . Isolation and characterization of a novel gene expressed in multiple cancers. . Oncogene . 12 . 4 . 741–51 . 1996 . 8632896 .
• Byrne JA, Mattei MG, Basset P . Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). . Genomics . 35 . 3 . 523–32 . 1996 . 8812487 . 10.1006/geno.1996.0393 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Byrne JA, Nourse CR, Basset P, Gunning P . Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. . Oncogene . 16 . 7 . 873–81 . 1998 . 9484778 . 10.1038/sj.onc.1201604 . 9948136 .
• Hoja MR, Wahlestedt C, Höög C . A visual intracellular classification strategy for uncharacterized human proteins. . Exp. Cell Res. . 259 . 1 . 239–46 . 2000 . 10942595 . 10.1006/excr.2000.4948 .
• Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA . Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system. . Genomics . 76 . 1–3 . 81–8 . 2001 . 11549320 . 10.1006/geno.2001.6610 .
• Sathasivam P, Bailey AM, Crossley M, Byrne JA . The role of the coiled-coil motif in interactions mediated by TPD52. . Biochem. Biophys. Res. Commun. . 288 . 1 . 56–61 . 2001 . 11594751 . 10.1006/bbrc.2001.5721 .
• Boutros R, Bailey AM, Wilson SH, Byrne JA . Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins. . J. Mol. Biol. . 332 . 3 . 675–87 . 2003 . 12963375 . 10.1016/S0022-2836(03)00944-6 .
• Wang R, Xu J, Saramäki O, Visakorpi T, Sutherland WM, Zhou J, Sen B, Lim SD, Mabjeesh N, Amin M, Dong JT, Petros JA, Nelson PS, Marshall FF, Zhau HE, Chung LW . PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer. . Cancer Res. . 64 . 5 . 1589–94 . 2004 . 14996714 . 10.1158/0008-5472.CAN-03-3331 . free .
• Tiacci E, Orvietani PL, Bigerna B, Pucciarini A, Corthals GL, Pettirossi V, Martelli MP, Liso A, Benedetti R, Pacini R, Bolli N, Pileri S, Pulford K, Gambacorta M, Carbone A, Pasquarello C, Scherl A, Robertson H, Sciurpi MT, Alunni-Bistocchi G, Binaglia L, Byrne JA, Falini B . Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca(2+)-dependent association with annexin VI. . Blood . 105 . 7 . 2812–20 . 2005 . 15576473 . 10.1182/blood-2004-07-2630 . free . 2434/602659 . free .
• Byrne JA, Balleine RL, Schoenberg Fejzo M, Mercieca J, Chiew YE, Livnat Y, St Heaps L, Peters GB, Byth K, Karlan BY, Slamon DJ, Harnett P, Defazio A . Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer. . Int. J. Cancer . 117 . 6 . 1049–54 . 2005 . 15986428 . 10.1002/ijc.21250 . 38845575 . free .
• Boutros R, Byrne JA . D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. . Exp. Cell Res. . 310 . 1 . 152–65 . 2005 . 16112108 . 10.1016/j.yexcr.2005.07.009 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Barbaric D, Byth K, Dalla-Pozza L, Byrne JA . Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations. . Leuk. Res. . 30 . 11 . 1355–63 . 2007 . 16620967 . 10.1016/j.leukres.2006.03.009 .
• Cao Q, Chen J, Zhu L, Liu Y, Zhou Z, Sha J, Wang S, Li J . A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. . Biochem. Biophys. Res. Commun. . 344 . 3 . 798–806 . 2006 . 16631610 . 10.1016/j.bbrc.2006.03.208 .

Notes and References

1. Byrne JA, Tomasetto C, Garnier JM, Rouyer N, Mattei MG, Bellocq JP, Rio MC, Basset P . A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence . Cancer Res . 55 . 13 . 2896–903 . August 1995 . 7796418 .
2. Web site: Entrez Gene: TPD52 tumor protein D52.
3. Byrne JA, Nourse CR, Basset P, Gunning P . Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system . Oncogene . 16 . 7 . 873–81 . February 1998 . 9484778 . 10.1038/sj.onc.1201604 . 9948136 .
4. Wilson SH, Bailey AM, Nourse CR, Mattei MG, Byrne JA . Identification of MAL2, a novel member of the mal proteolipid family, though interactions with TPD52-like proteins in the yeast two-hybrid system . Genomics . 76 . 1–3 . 81–8 . August 2001 . 11549320 . 10.1006/geno.2001.6610 .