TP73-AS1 explained

In molecular biology, P73 antisense RNA 1T (non-protein coding), also known as TP73-AS1 or PDAM, is a long non-coding RNA. It may regulate apoptosis via regulation of p53-dependent anti-apoptotic genes. It may play a role in the development of oligodendroglial tumours.^[1]

Further reading

• Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O . Characterization of cDNA clones in size-fractionated cDNA libraries from human brain . DNA Research . 4 . 5 . 345–349 . October 1997 . 9455484 . 10.1093/dnares/4.5.345 . free .

Notes and References

1. Pang JC, Li KK, Lau KM, Ng YL, Wong J, Chung NY, Li HM, Chui YL, Lui VW, Chen ZP, Chan DT, Poon WS, Wang Y, Mao Y, Zhou L, Ng HK . KIAA0495/PDAM is frequently downregulated in oligodendroglial tumors and its knockdown by siRNA induces cisplatin resistance in glioma cells . Brain Pathology . 20 . 6 . 1021–1032 . November 2010 . 20477830 . 10.1111/j.1750-3639.2010.00405.x . 8094719 .