TP53RK explained

TP53-regulating kinase, also known as PRPK is an enzyme that in humans is encoded by the TP53RK gene.^{[1] [2] [3]} This protein is a serine/threonine protein kinase that phosphorylates p53 at Ser15.

PRPK is part of the KEOPS/EKC complex, which participates in transcription control,^[4] telomere regulation ^[5] and tRNA modification.^[6]

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Research . 6 . 9 . 791–806 . Sep 1996 . 8889548 . 10.1101/gr.6.9.791 . free .
• Miyoshi A, Kito K, Aramoto T, Abe Y, Kobayashi N, Ueda N . Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein . Biochemical and Biophysical Research Communications . 303 . 2 . 399–405 . Apr 2003 . 12659830 . 10.1016/S0006-291X(03)00333-4 .
• Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC . Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2 . Cancer Cell . 6 . 3 . 251–61 . Sep 2004 . 15380516 . 10.1016/j.ccr.2004.07.012 . free .
• Abe Y, Takeuchi T, Imai Y, Murase R, Kamei Y, Fujibuchi T, Matsumoto S, Ueda N, Ogasawara M, Shigemoto K, Kito K . A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK . Biochemical and Biophysical Research Communications . 344 . 1 . 377–85 . May 2006 . 16600182 . 10.1016/j.bbrc.2006.03.071 .

Notes and References

1. Abe Y, Matsumoto S, Wei S, Nezu K, Miyoshi A, Kito K, Ueda N, Shigemoto K, Hitsumoto Y, Nikawa J, Enomoto Y . Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes . The Journal of Biological Chemistry . 276 . 47 . 44003–11 . Nov 2001 . 11546806 . 10.1074/jbc.M105669200 . free .
2. Facchin S, Lopreiato R, Ruzzene M, Marin O, Sartori G, Götz C, Montenarh M, Carignani G, Pinna LA . Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency . FEBS Letters . 549 . 1–3 . 63–6 . Aug 2003 . 12914926 . 10.1016/S0014-5793(03)00770-1 . 24581860 .
3. Web site: Entrez Gene: TP53RK TP53 regulating kinase.
4. Kisseleva-Romanova E, Lopreiato R, Baudin-Baillieu A, Rousselle JC, Ilan L, Hofmann K, Namane A, Mann C, Libri D . Yeast homolog of a cancer-testis antigen defines a new transcription complex . The EMBO Journal . 25 . 15 . 3576–85 . Aug 2006 . 16874308 . 1538566. 10.1038/sj.emboj.7601235 .
5. Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D . A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator . Cell . 124 . 6 . 1155–68 . Mar 2006 . 16564010 . 10.1016/j.cell.2005.12.044 . 13928061 . free .
6. Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R . The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A . The EMBO Journal . 30 . 5 . 873–81 . Mar 2011 . 21183954 . 3049205. 10.1038/emboj.2010.343 .