TP53INP1 explained

Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene.^{[1] [2] [3]} In mice this protein is also called TRP53INP1 and is encoded by the Trp53inp1 gene. The protein is also referred to as SIP or "stress inducible protein"

Interactions

TP53INP1 has been shown to interact with HIPK2^[4] and p53.^[4]

Further reading

• Tomasini R . P53-dependent expression of the stress-induced protein (SIP) . Eur. J. Cell Biol. . 81 . 5 . 294–301 . 2003 . 12067065 . 10.1078/0171-9335-00248 . vanc. Samir AA . Pebusque MJ . 3 . Calvo . EL . Totaro . S . Dagorn . JC . Dusetti . NJ . Iovanna . JL .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Tomasini R . TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity . J. Biol. Chem. . 278 . 39 . 37722–9 . 2003 . 12851404 . 10.1074/jbc.M301979200 . vanc. Samir AA . Carrier A . 3 . Isnardon . D . Cecchinelli . B . Soddu . S . Malissen . B . Dagorn . JC . Iovanna . JL . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Hershko T, Chaussepied M, Oren M, Ginsberg D . Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F . Cell Death Differ. . 12 . 4 . 377–83 . 2005 . 15706352 . 10.1038/sj.cdd.4401575 . free .
• Tomasini R . TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity . Oncogene . 24 . 55 . 8093–104 . 2006 . 16044147 . 10.1038/sj.onc.1208951 . vanc. Seux M . Nowak J . 3 . Bontemps . Caroline . Carrier . Alice . Dagorn . Jean-Charles . Pébusque . Marie-Josèphe . Iovanna . Juan L . Dusetti . Nelson J . free .
• Jiang PH . Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer . World J. Gastroenterol. . 12 . 5 . 691–6 . 2006 . 16521180 . 10.3748/wjg.v12.i5.691. vanc. Motoo Y . Garcia S . 3 . Iovanna . JL . Pébusque . MJ . Sawabu . N . 4066117 . free.
• Ito Y . High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid . Pathology . 38 . 6 . 545–7 . 2007 . 17393983 . 10.1080/00313020601024094 . vanc. Motoo Y . Yoshida H . 3 . Iovanna . Juan Lucio . Nakamura . Yasushi . Kuma . Kanji . Miyauchi . Akira . 28578199 .
• Bernardo MV . Identification of apoptosis-related PLZF target genes . Biochem. Biophys. Res. Commun. . 359 . 2 . 317–22 . 2007 . 17537403 . 10.1016/j.bbrc.2007.05.085 . vanc. Yelo E . Gimeno L . 3 . Campillo . José Antonio . Parrado . Antonio .

Notes and References

1. Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M, Nakamura Y . p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis . Mol Cell . 8 . 1 . 85–94 . Aug 2001 . 11511362 . 10.1016/S1097-2765(01)00284-2 . free .
2. Nowak J, Tomasini R, Mattei MG, Azizi Samir LA, Dagorn JC, Dusetti N, Iovanna JL, Pebusque MJ . Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization . Cytogenet Genome Res . 97 . 1–2 . 140E . Nov 2002 . 12438758 . 10.1159/000064049 . free .
3. Web site: Entrez Gene: TP53INP1 tumor protein p53 inducible nuclear protein 1.
4. Tomasini . Richard . Samir Amina Azizi . Carrier Alice . Isnardon Daniel . Cecchinelli Barbara . Soddu Silvia . Malissen Bernard . Dagorn Jean-Charles . Iovanna Juan L . Dusetti Nelson J . Sep 2003 . TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity . J. Biol. Chem. . 278 . 39 . 37722–9 . United States. 0021-9258. 12851404 . 10.1074/jbc.M301979200 . free .