TP53I3 explained

Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene.^{[1] [2] [3] [4]}

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.^[5]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Polyak K, Xia Y, Zweier JL, etal . A model for p53-induced apoptosis . Nature . 389 . 6648 . 300–5 . 1997 . 9305847 . 10.1038/38525 . 1997Natur.389..300P . 4429638 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Nicholls CD, Shields MA, Lee PW, etal . UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation . J. Biol. Chem. . 279 . 23 . 24171–8 . 2004 . 15067011 . 10.1074/jbc.M401049200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4 . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Rohaly G, Chemnitz J, Dehde S, etal . A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint . Cell . 122 . 1 . 21–32 . 2005 . 16009130 . 10.1016/j.cell.2005.04.032 . 2350226 . free .
• Stelzl U, Worm U, Lalowski M, etal . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .

Notes and References

1. Contente A, Dittmer A, Koch MC, Roth J, Dobbelstein M . A polymorphic microsatellite that mediates induction of PIG3 by p53 . Nat Genet . 30 . 3 . 315–20 . Mar 2002 . 11919562 . 10.1038/ng836 . 19112465 .
2. Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE, Pietenpol JA . p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest . Cancer Lett . 156 . 1 . 63–72 . Jul 2000 . 10840161 . 10.1016/S0304-3835(00)00441-9 .
3. Porte S, Valencia E, Yakovtseva EA, Borras E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farres J, Fita I, Pares X . Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3 . J Biol Chem . 284 . 25 . 17194–205 . Jun 2009 . 19349281 . 2719357 . 10.1074/jbc.M109.001800 . free .
4. Web site: Entrez Gene: TP53I3 tumor protein p53 inducible protein 3.
5. Web site: Entrez Gene: TP53I3 tumor protein p53 inducible protein 3.