TP-003 explained

TP-003 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a positive allosteric modulator at the benzodiazepine binding site of GABA_A receptors.^[1] It has modest anticonvulsant activity although less than that of diazepam.^[2]

See also

• Imidazopyridine
• L-838,417

References

1. Neumann E, Ralvenius WT, Acuña MA, Rudolph U, Zeilhofer HU . TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors . Neuropharmacology . 143. 71–78. 2018 . 30240781 . 10.1016/j.neuropharm.2018.09.026 . 52313196 .
2. Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR . Jun 2007 . Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands . Journal of Psychopharmacology . 21 . 4. 384–91 . 17092983 . 10.1177/0269881106067255 . 34355306 .