CRTC2 explained

CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.^{[1] [2] [3]}

Function

CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.^[4] CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC).^[5]

Interactions

CRTC2 has been shown to interact with SNF1LK2^[6] and YWHAQ.^{[6] [7]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA . 6 . Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells . Proceedings of the National Academy of Sciences of the United States of America . 100 . 21 . 12147–52 . October 2003 . 14506290 . 218727 . 10.1073/pnas.1932773100 . free .
• Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M . TORCs: transducers of regulated CREB activity . Molecular Cell . 12 . 2 . 413–23 . August 2003 . 14536081 . 10.1016/j.molcel.2003.08.013 . free .
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T . 6 . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Current Biology . 14 . 16 . 1436–50 . August 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M . 6 . The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector . Cell . 119 . 1 . 61–74 . October 2004 . 15454081 . 10.1016/j.cell.2004.09.015 . 18616459 . free .
• Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR . 6 . 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK . Journal of Cell Science . 118 . Pt 23 . 5661–73 . December 2005 . 16306228 . 10.1242/jcs.02670 . 17404931 .
• Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY . TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats . Journal of Virology . 80 . 14 . 7052–9 . July 2006 . 16809310 . 1489057 . 10.1128/JVI.00103-06 .
• Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC . 6 . Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells . Proceedings of the National Academy of Sciences of the United States of America . 103 . 39 . 14379–84 . September 2006 . 16980408 . 1569674 . 10.1073/pnas.0606714103 . 2006PNAS..10314379W . free .
• Yang Q, Inoki K, Ikenoue T, Guan KL . Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity . Genes & Development . 20 . 20 . 2820–32 . October 2006 . 17043309 . 1619946 . 10.1101/gad.1461206 .
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . 6 . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .
• Ravnskjaer K, Kester H, Liu Y, Zhang X, Lee D, Yates JR, Montminy M . Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression . The EMBO Journal . 26 . 12 . 2880–9 . June 2007 . 17476304 . 1894761 . 10.1038/sj.emboj.7601715 .
• Kuraishy AI, French SW, Sherman M, Herling M, Jones D, Wall R, Teitell MA . TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation . Proceedings of the National Academy of Sciences of the United States of America . 104 . 24 . 10175–80 . June 2007 . 17548807 . 1891214 . 10.1073/pnas.0704170104 . 2007PNAS..10410175K . free .

Notes and References

1. Web site: Entrez Gene: CRTC2 CREB regulated transcription coactivator 2.
2. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA . 6 . Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells . Proceedings of the National Academy of Sciences of the United States of America . 100 . 21 . 12147–52 . October 2003 . 14506290 . 218727 . 10.1073/pnas.1932773100 . free .
3. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M . TORCs: transducers of regulated CREB activity . Molecular Cell . 12 . 2 . 413–23 . August 2003 . 14536081 . 10.1016/j.molcel.2003.08.013 . free .
4. Cheng A, Saltiel AR . More TORC for the gluconeogenic engine . BioEssays . 28 . 3 . 231–4 . March 2006 . 16479585 . 10.1002/bies.20375 . 10.1.1.604.5745 .
5. Rodón L, Svensson RU, Wiater E, Chun MG, Tsai WW, Eichner LJ, Shaw RJ, Montminy M . 6 . The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer . Science Advances . 5 . 7 . eaaw6455 . July 2019 . 31355336 . 6656544 . 10.1126/sciadv.aaw6455 . 2019SciA....5.6455R .
6. Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M . 6 . The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector . Cell . 119 . 1 . 61–74 . October 2004 . 15454081 . 10.1016/j.cell.2004.09.015 . 18616459 . free .
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . 6 . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 1 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .