TOPORS explained

E3 ubiquitin-protein ligase Topors is an enzyme that in humans is encoded by the TOPORS gene.^{[1] [2] [3] [4]}

Further reading

• Zhou R, Wen H, Ao SZ . Identification of a novel gene encoding a p53-associated protein. . Gene . 235 . 1–2 . 93–101 . 1999 . 10415337 . 10.1016/S0378-1119(99)00203-6 .
• Souto-Carneiro MM, Krenn V, Hermann R, etal . IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process . Arthritis Res. . 2 . 4 . 303–14 . 2001 . 11056671 . 10.1186/ar105 . 17813 . free .
• Chu D, Kakazu N, Gorrin-Rivas MJ, etal . Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence . J. Biol. Chem. . 276 . 17 . 14004–13 . 2001 . 11278651 . 10.1074/jbc.M010262200 . 2433/150162 . 20734219 . free .
• Weger S, Hammer E, Heilbronn R . Topors, a p53 and topoisomerase I binding protein, interacts with the adeno-associated virus (AAV-2) Rep78/68 proteins and enhances AAV-2 gene expression . J. Gen. Virol. . 83 . Pt 3 . 511–6 . 2002 . 11842245 . 10.1099/0022-1317-83-3-511. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Imabayashi H, Mori T, Gojo S, etal . Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis . Exp. Cell Res. . 288 . 1 . 35–50 . 2003 . 12878157 . 10.1016/S0014-4827(03)00130-7 .
• Weger S, Hammer E, Engstler M . The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation . Exp. Cell Res. . 290 . 1 . 13–27 . 2003 . 14516784 . 10.1016/S0014-4827(03)00292-1 .
• Saleem A, Dutta J, Malegaonkar D, etal . The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor . Oncogene . 23 . 31 . 5293–300 . 2004 . 15107820 . 10.1038/sj.onc.1207700 . free .
• Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H .
• Colland F, Jacq X, Trouplin V, etal . Functional proteomics mapping of a human signaling pathway . Genome Res. . 14 . 7 . 1324–32 . 2004 . 15231748 . 10.1101/gr.2334104 . 442148 .
• Rajendra R, Malegaonkar D, Pungaliya P, etal . Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53 . J. Biol. Chem. . 279 . 35 . 36440–4 . 2004 . 15247280 . 10.1074/jbc.C400300200 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Oyanagi H, Takenaka K, Ishikawa S, etal . Expression of LUN gene that encodes a novel RING finger protein is correlated with development and progression of non-small cell lung cancer . Lung Cancer . 46 . 1 . 21–8 . 2005 . 15364129 . 10.1016/j.lungcan.2004.03.009 . 2433/145282 . 33682022 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Flatten K, Dai NT, Vroman BT, etal . The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons . J. Biol. Chem. . 280 . 14 . 14349–55 . 2005 . 15699047 . 10.1074/jbc.M411890200 . free .
• Lin L, Ozaki T, Takada Y, etal . topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage . Oncogene . 24 . 21 . 3385–96 . 2005 . 15735665 . 10.1038/sj.onc.1208554 . free .
• Weger S, Hammer E, Heilbronn R . Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo . FEBS Lett. . 579 . 22 . 5007–12 . 2005 . 16122737 . 10.1016/j.febslet.2005.07.088 . 40285751 .
• Papaioannou M, Chakarova CF, Prescott DC, etal . A new locus (RP31) for autosomal dominant retinitis pigmentosa maps to chromosome 9p . Hum. Genet. . 118 . 3–4 . 501–3 . 2006 . 16189705 . 10.1007/s00439-005-0063-3 . 28018465 .

Notes and References

1. ((Haluska P Jr)), Saleem A, Rasheed Z, Ahmed F, Su EW, Liu LF, Rubin EH . Leroy Liu . Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein . Nucleic Acids Res . 27 . 12 . 2538–44 . Jul 1999 . 10352183 . 148458 . 10.1093/nar/27.12.2538 .
2. Rasheed ZA, Saleem A, Ravee Y, Pandolfi PP, Rubin EH . The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies . Exp Cell Res . 277 . 2 . 152–60 . Jun 2002 . 12083797 . 10.1006/excr.2002.5550 .
3. Chakarova CF, Papaioannou MG, Khanna H, Lopez I, Waseem N, Shah A, Theis T, Friedman J, Maubaret C, Bujakowska K, Veraitch B, Abd El-Aziz MM, Prescott de Q, Parapuram SK, Bickmore WA, Munro PM, Gal A, Hamel CP, Marigo V, Ponting CP, Wissinger B, Zrenner E, Matter K, Swaroop A, Koenekoop RK, Bhattacharya SS . Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy . Am J Hum Genet . 81 . 5 . 1098–103 . Oct 2007 . 17924349 . 2265653 . 10.1086/521953 .
4. Web site: Entrez Gene: TOPORS topoisomerase I binding, arginine/serine-rich.