TOMM34 explained

Mitochondrial import receptor subunit TOM34 is a protein that in humans is encoded by the TOMM34 gene.^{[1] [2]}

The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Young JC, Obermann WM, Hartl FU . Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90 . J. Biol. Chem. . 273 . 29 . 18007–10 . 1998 . 9660753 . 10.1074/jbc.273.29.18007 . free .
• Chewawiwat N, Yano M, Terada K, etal . Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells . J. Biochem. . 125 . 4 . 721–7 . 1999 . 10101285 . 10.1093/oxfordjournals.jbchem.a022342.
• Fossey SC, Mychaleckyj JC, Pendleton JK, etal . A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 . Genomics . 76 . 1–3 . 45–57 . 2001 . 11549316 . 10.1006/geno.2001.6584 .
• Deloukas P, Matthews LH, Ashurst J, etal . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–71 . 2002 . 11780052 . 10.1038/414865a . 2001Natur.414..865D . free .
• Mukhopadhyay A, Avramova LV, Weiner H . Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins . Arch. Biochem. Biophys. . 400 . 1 . 97–104 . 2002 . 11913975 . 10.1006/abbi.2002.2777 .
• Yang CS, Weiner H . Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol . Arch. Biochem. Biophys. . 400 . 1 . 105–10 . 2002 . 11913976 . 10.1006/abbi.2002.2778 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Shimokawa T, Matsushima S, Tsunoda T, etal . Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target . Int. J. Oncol. . 29 . 2 . 381–6 . 2006 . 16820880 . 10.3892/ijo.29.2.381. free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Nuttall SD, Hanson BJ, Mori M, Hoogenraad NJ . hTom34: a novel translocase for the import of proteins into human mitochondria . DNA Cell Biol . 16 . 9 . 1067–74 . Oct 1997 . 9324309 . 10.1089/dna.1997.16.1067 .
2. Web site: Entrez Gene: TOMM34 translocase of outer mitochondrial membrane 34.