TOMM22 explained

Mitochondrial import receptor subunit TOM22 homolog (hTom22) is a protein that in humans is encoded by the TOMM22 gene.^{[1] [2] [3]}

The protein encoded by this gene is an integral membrane protein of the outer mitochondrial membrane. The encoded protein interacts with TOMM20 and TOMM40, and with other proteins forms a complex – the translocase of the outer membrane, to import cytosolic preproteins into the mitochondrion.^[4]

See also

• TOMM20
• TOMM40
• TOMM70A

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Suzuki H, Okazawa Y, Komiya T, etal . Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane . J. Biol. Chem. . 275 . 48 . 37930–6 . 2001 . 10980201 . 10.1074/jbc.M006558200 . free .
• Johnston AJ, Hoogenraad J, Dougan DA, etal . Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane . J. Biol. Chem. . 277 . 44 . 42197–204 . 2003 . 12198123 . 10.1074/jbc.M205613200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Yano M, Terada K, Mori M . AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins . J. Cell Biol. . 163 . 1 . 45–56 . 2003 . 14557246 . 10.1083/jcb.200305051 . 2173431 .
• Yano M, Terada K, Mori M . Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity . J. Biol. Chem. . 279 . 11 . 10808–13 . 2004 . 14699115 . 10.1074/jbc.M311710200 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Collins JE, Wright CL, Edwards CA, etal . A genome annotation-driven approach to cloning the human ORFeome . Genome Biol. . 5 . 10 . R84 . 2005 . 15461802 . 10.1186/gb-2004-5-10-r84 . 545604 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Humphries AD, Streimann IC, Stojanovski D, etal . Dissection of the mitochondrial import and assembly pathway for human Tom40 . J. Biol. Chem. . 280 . 12 . 11535–43 . 2005 . 15644312 . 10.1074/jbc.M413816200 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . free .
• Bellot G, Cartron PF, Er E, etal . TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax . Cell Death Differ. . 14 . 4 . 785–94 . 2007 . 17096026 . 10.1038/sj.cdd.4402055 . free .

Notes and References

1. Yano M, Hoogenraad N, Terada K, Mori M . Identification and functional analysis of human Tom22 for protein import into mitochondria . Mol Cell Biol . 20 . 19 . 7205–13 . Oct 2000 . 10982837 . 86274 . 10.1128/MCB.20.19.7205-7213.2000 .
2. Saeki K, Suzuki H, Tsuneoka M, Maeda M, Iwamoto R, Hasuwa H, Shida S, Takahashi T, Sakaguchi M, Endo T, Miura Y, Mekada E, Mihara K . Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane . J Biol Chem . 275 . 41 . 31996–2002 . Nov 2000 . 10900208 . 10.1074/jbc.M004794200 . free .
3. Web site: Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast).
4. Web site: Entrez Gene: TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast).